过氧化氢检测试剂盒
产品编号: S0038
产品包装:150次
选择包装
150次
数
量
过氧化氢检测试剂盒(S0038)
说明书下载
价格: ¥ 985.00
产品简介
使用说明
产品图片
相关产品
相关论文
产品问答
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| S0038 | 过氧化氢检测试剂盒 | 150次 | 985.00元 |
过氧化氢检测试剂盒(Hydrogen Peroxide Assay Kit)可以用于培养细胞或组织内过氧化氢水平的测定，也可以用于培养细胞的上清或血清、尿液、血浆或其它生物体液中的过氧化氢浓度的测定。
过氧化氢是一种活性氧代谢的副产物，在许多氧化应急反应中过氧化氢都是一种关键的调节因子。过氧化氢可以激活NF-κB等因子，这些过氧化氢相关的信号途径和哮喘、炎症性关节炎、动脉硬化以及神经退行性疾病等许多疾病相关。过氧化氢也和细胞凋亡、细胞增殖等密切相关。
本试剂盒通过过氧化氢氧化二价铁离子产生三价铁离子，然后和xylenol orange在特定的溶液中形成紫色的产物，从而实现对过氧化氢浓度的测定。本试剂盒经过改良配方，可以检测低达1微摩尔/升的过氧化氢。
本试剂盒方便快捷，通常10-20个样品可以在40-60分钟内测定完毕。
本试剂盒可以检测150个样品。
包装清单：
| 产品编号 | 产品名称 | 包装 |
| S0038-1 | 过氧化氢检测试剂 | 15ml |
| S0038-2 | 过氧化氢标准溶液(1M) | 1ml |
| S0038-3 | 过氧化氢检测裂解液 | 50ml |
| — | 说明书 | 1份 |
保存条件：
-20℃保存，一年有效。其中过氧化氢标准溶液需避光保存。
注意事项：
一些干扰氧化还原的试剂或在酸性条件下呈紫色或接近的试剂会对过氧化氢的检测产生干扰，需尽量避免。
如果样品中含有外加的较高浓度的铁盐，会干扰测定。但普通培养基、血清等样品中含有的微量的铁盐不会干扰测定。
所测得的标准曲线尽管在一定的浓度范围内接近直线，但整个标准曲线不是直线。
测定时需可以测定A560的酶标仪一台(测540-570nm也可以)或可以测定微量样品的分光光度计一台。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
使用说明：
1.样品测定的准备：
a.细胞或组织样品的制备
对于培养的细胞，先收集细胞到离心管内，弃上清，按照每100万细胞加入100-200微升过氧化氢检测裂解液的比例加入裂解液，随后充分匀浆以破碎并裂解细胞。4℃约12000g离心3-5分钟，取上清，用于后续测定。组织样品按照每5-10mg组织加入100-200微升裂解液的比例进行匀浆。4℃约12000g离心3-5分钟，取上清用于后续测定。以上所有操作均需在4℃或冰上操作。制备好的细胞或组织样品如果不立即测定，可以-20℃冻存。
b.培养细胞上清液样品的制备
培养细胞的上清液可以直接用于后续的测定。
c.血清、血浆或尿液样品的准备：
配制50mM磷酸缓冲液，pH为6.0。用pH为6.0的50mM磷酸缓冲液把样品稀释50倍。例如4微升样品稀释到196微升pH为6.0的50mM磷酸缓冲液中。稀释后即可用于后续的测定。
2.标准曲线测定的准备：
a.过氧化氢标准品的校准：
由于过氧化氢不是非常稳定，使用前需自行测定过氧化氢的实际浓度以进行校准。把浓度约为1M的过氧化氢用水稀释100倍，使过氧化氢的浓度约为10mM，测定A240。A240的测定可采用如下的任一方法：
(a)普通紫外分光光度计法：使用含比色皿架的紫外分光光度计、NanoDrop 2000C、NanoDrop Oneᶜ、QuickDrop等仪器，配套石英比色皿。确定比色皿光程(path length)，一般为1cm。用比色皿检测的过氧化氢浓度最接近实际浓度。
(b)微量紫外分光光度计法：如NanoDrop 2000、NanoDrop One、QuickDrop、含超微量检测板µDrop Plate的Varioskan等仪器。确定光程：对于NanoDrop 2000、NanoDrop One等，需要取消“自动化光程”，此时光程一般为0.1cm；Varioskan的超微量检测板µDrop Plate的光程一般为0.05cm。具体的微量紫外分光光度计的光程请参考仪器参数。
(c)96孔紫外酶标仪法(须能检测240nm波长)：根据96孔板的参数确定光程，一般200微升样品的光程为0.552cm (样品体积除以96孔单孔孔内横截面面积)。一般建议使用专用的96孔紫外检测板(如96孔UV板)，如果没有紫外检测板，也可使用一般的96孔板，但由于为非紫外检测专用板，会有非常高的紫外吸收信号，所以需要设置含等量双蒸水的孔作为空白对照(一般200μl水在该类96孔板的A240在3.8左右)，计算时须减去该空白对照。在使用非紫外检测专用板的情况下，由于96孔酶标仪在240nm的检测上限有限，建议将过氧化氢稀释至约10mM左右后再进行浓度测定。
注意：以上所有方法都需要设置等量双蒸水作为空白对照，并在计算时减去该空白对照。
浓度计算公式：c=A/(ε×b)。其中：c为样品浓度(单位为mol/L或M)；A为吸光值；ε为波长依赖的摩尔消光系数(单位为L×mol-1×cm-1或M-1×cm-1)，过氧化氢的摩尔消光系数为43.6M-1cm-1；b=光程(单位为cm)。
因此：过氧化氢浓度(M)=A240/(43.6×b)；即：过氧化氢浓度(mM)=22.94 X A240/b
从而计算出本试剂盒提供的过氧化氢的实际浓度，并根据实际测定出来的浓度进行后续的标准曲线的设置。
示例：将本试剂盒提供的约为1M的过氧化氢用双蒸水稀释100倍后，用96孔酶标仪及一般的96孔板进行检测，每孔200微升，每组3个平行。双蒸水对照组的平均A240为3.750，过氧化氢样品组的平均A240为3.974，差值为0.224，200微升样品的光程为0.552cm。代入公式，过氧化氢浓度(mM)=22.94×0.224/0.552=9.31，则实际本试剂盒提供的过氧化氢浓度为0.931M。
b.标准曲线的设置：
样品在什么溶液中标准品也需用什么溶液稀释，这样可以减小误差。例如对于细胞样品，标准品宜用过氧化氢检测裂解液稀释，对于培养细胞的上清液样品，标准品宜用相应的细胞培养液稀释。标准溶液可以稀释成1、3、10、30、100微摩尔/升，或1、2、5、10、20、50、100微摩尔/升，初次测定后知道样品的浓度范围后可以对标准品在样品浓度范围附近密集测定。
3. 过氧化氢浓度的测定：
a.把过氧化氢检测试剂在冰上或冰水浴上融解。
b.在检测孔或检测管内加入50微升样品或标准品。
c.在每个孔内加入100微升过氧化氢检测试剂。
d.轻轻振荡或敲打混匀，室温(15-30℃)放置30分钟。然后立即测定A560。如测A560有困难，波长可以选择540-570nm。
e.根据标准曲线计算出样品中过氧化氢的浓度。
注意：如果样品中过氧化氢的浓度过高，可以适当稀释后再测定。如果样品中过氧化氢的浓度过低，可以把样品的体积改为使用100微升，同时标准品也使用100微升，而检测试剂仍然 使用100微升。这样可以提高检测的灵敏度，但缺点是样品需要消耗100微升。
1.样品测定的准备：
a.细胞或组织样品的制备
对于培养的细胞，先收集细胞到离心管内，弃上清，按照每100万细胞加入100-200微升过氧化氢检测裂解液的比例加入裂解液，随后充分匀浆以破碎并裂解细胞。4℃约12000g离心3-5分钟，取上清，用于后续测定。组织样品按照每5-10mg组织加入100-200微升裂解液的比例进行匀浆。4℃约12000g离心3-5分钟，取上清用于后续测定。以上所有操作均需在4℃或冰上操作。制备好的细胞或组织样品如果不立即测定，可以-20℃冻存。
b.培养细胞上清液样品的制备
培养细胞的上清液可以直接用于后续的测定。
c.血清、血浆或尿液样品的准备：
配制50mM磷酸缓冲液，pH为6.0。用pH为6.0的50mM磷酸缓冲液把样品稀释50倍。例如4微升样品稀释到196微升pH为6.0的50mM磷酸缓冲液中。稀释后即可用于后续的测定。
2.标准曲线测定的准备：
a.过氧化氢标准品的校准：
由于过氧化氢不是非常稳定，使用前需自行测定过氧化氢的实际浓度以进行校准。把浓度约为1M的过氧化氢用水稀释100倍，使过氧化氢的浓度约为10mM，测定A240。A240的测定可采用如下的任一方法：
(a)普通紫外分光光度计法：使用含比色皿架的紫外分光光度计、NanoDrop 2000C、NanoDrop Oneᶜ、QuickDrop等仪器，配套石英比色皿。确定比色皿光程(path length)，一般为1cm。用比色皿检测的过氧化氢浓度最接近实际浓度。
(b)微量紫外分光光度计法：如NanoDrop 2000、NanoDrop One、QuickDrop、含超微量检测板µDrop Plate的Varioskan等仪器。确定光程：对于NanoDrop 2000、NanoDrop One等，需要取消“自动化光程”，此时光程一般为0.1cm；Varioskan的超微量检测板µDrop Plate的光程一般为0.05cm。具体的微量紫外分光光度计的光程请参考仪器参数。
(c)96孔紫外酶标仪法(须能检测240nm波长)：根据96孔板的参数确定光程，一般200微升样品的光程为0.552cm (样品体积除以96孔单孔孔内横截面面积)。一般建议使用专用的96孔紫外检测板(如96孔UV板)，如果没有紫外检测板，也可使用一般的96孔板，但由于为非紫外检测专用板，会有非常高的紫外吸收信号，所以需要设置含等量双蒸水的孔作为空白对照(一般200μl水在该类96孔板的A240在3.8左右)，计算时须减去该空白对照。在使用非紫外检测专用板的情况下，由于96孔酶标仪在240nm的检测上限有限，建议将过氧化氢稀释至约10mM左右后再进行浓度测定。
注意：以上所有方法都需要设置等量双蒸水作为空白对照，并在计算时减去该空白对照。
浓度计算公式：c=A/(ε×b)。其中：c为样品浓度(单位为mol/L或M)；A为吸光值；ε为波长依赖的摩尔消光系数(单位为L×mol-1×cm-1或M-1×cm-1)，过氧化氢的摩尔消光系数为43.6M-1cm-1；b=光程(单位为cm)。
因此：过氧化氢浓度(M)=A240/(43.6×b)；即：过氧化氢浓度(mM)=22.94 X A240/b
从而计算出本试剂盒提供的过氧化氢的实际浓度，并根据实际测定出来的浓度进行后续的标准曲线的设置。
示例：将本试剂盒提供的约为1M的过氧化氢用双蒸水稀释100倍后，用96孔酶标仪及一般的96孔板进行检测，每孔200微升，每组3个平行。双蒸水对照组的平均A240为3.750，过氧化氢样品组的平均A240为3.974，差值为0.224，200微升样品的光程为0.552cm。代入公式，过氧化氢浓度(mM)=22.94×0.224/0.552=9.31，则实际本试剂盒提供的过氧化氢浓度为0.931M。
b.标准曲线的设置：
样品在什么溶液中标准品也需用什么溶液稀释，这样可以减小误差。例如对于细胞样品，标准品宜用过氧化氢检测裂解液稀释，对于培养细胞的上清液样品，标准品宜用相应的细胞培养液稀释。标准溶液可以稀释成1、3、10、30、100微摩尔/升，或1、2、5、10、20、50、100微摩尔/升，初次测定后知道样品的浓度范围后可以对标准品在样品浓度范围附近密集测定。
3. 过氧化氢浓度的测定：
a.把过氧化氢检测试剂在冰上或冰水浴上融解。
b.在检测孔或检测管内加入50微升样品或标准品。
c.在每个孔内加入100微升过氧化氢检测试剂。
d.轻轻振荡或敲打混匀，室温(15-30℃)放置30分钟。然后立即测定A560。如测A560有困难，波长可以选择540-570nm。
e.根据标准曲线计算出样品中过氧化氢的浓度。
注意：如果样品中过氧化氢的浓度过高，可以适当稀释后再测定。如果样品中过氧化氢的浓度过低，可以把样品的体积改为使用100微升，同时标准品也使用100微升，而检测试剂仍然 使用100微升。这样可以提高检测的灵敏度，但缺点是样品需要消耗100微升。
相关产品请点击如下按钮：
活性氧相关
使用本产品的文献：
1. Dai X, Sun Y, Jiang Z.
Protective Effects of Vitamin Eagainst Oxidative Damage Induced by Abeta(1-40)Cu(II) Complexes.
ACTA BIOCH BIOPH SIN . 2007 Feb;39(2):123-30. (IF 2.836)
2. Gao S, Liu C, Qu S, Song J, Li J, Zhang P, Wang Q, Guo C, Gao F, Zhang L.
Non-cell Corynebacterium parvum generated by nanotechnology: a promising immunomodulator with less side effects.
Int Immunopharmacol . 2007 Oct;7(10):1334-42. (IF 3.943)
3. Qian H, Chen W, Li J, Wang J, Zhou Z, Liu W, Fu Z.
The effect of exogenous nitric oxide on alleviating herbicide damage in Chlorella vulgaris.
Aquat Toxicol . 2009 May 17;92(4):250-7. (IF 4.344)
4. Sheng R, Gu ZL, Xie ML, Zhou WX, Guo CY.
Epigallocatechin gallate protects H9c2 cardiomyoblasts against hydrogen dioxides-induced apoptosis and telomere attrition.
Eur J Pharmacol . 2010;641(2-3):199-206. (IF 3.263)
5. Dai X, Sun Y, Gao Z, Jiang Z.
Copper Enhances Amyloid-beta Peptide Neurotoxicity and non beta-Aggregation: A Series of Experiments Conducted upon Copper-Bound and Copper-Free Amyloid-beta Peptide.
J Mol Neurosci . 2010 May;41(1):66-73. (IF 2.678)
6. Yang Q, Gong ZJ, Zhou Y, Yuan JQ, Cheng J, Tian L, Li S, Lin XD, Xu R, Zhu ZR, Mao C.
Role of Drosophila alkaline ceramidase (Dacer) in Drosophila development and longevity.
Cell Mol Life Sci . 2010 May;67(9):1477-90. (IF 6.496)
7. Dai X, Sun Y, Gao Z, Jiang Z.
Copper enhances amyloid-beta peptide neurotoxicity and non beta-aggregation: a series ofexperiments conducted upon copper-bound and copper-free amyloid-beta peptide.
J Mol Neurosci . 2010 May;41(1):66-73. (IF 2.678)
8. Huang HC, Lin CJ, Liu WJ, Jiang RR, Jiang ZF.
Dual effects of curcumin on neuronal oxidative stress in the presence of Cu(II).
Food Chem Toxicol . 2011 Jul;49(7):1578-83. (IF 4.679)
9. Jiang S, Zu Y, Wang Z, Zhang Y, Fu Y.
Involvement of mitochondrial permeability transition pore opening in 7-xylosyl-10-deacetylpaclitaxel-induced apoptosis.
Planta Med . 2011 Jul;77(10):1005-12. (IF 2.687)
10. Shi R, Hu C, Yuan Q, Yang T, Peng J, Li Y, Bai Y, Cao Z, Cheng G, Zhang G.
Involvement of vascular peroxidase 1 in angiotensin II-induced vascular smooth muscle cellproliferation.
Cardiovasc Res . 2011 Jul 1;91(1):27-36. (IF 8.168)
11. Dai X, Chang P, Liu W, Xu K, Sun Y, Zhu S, Jiang Z.
Aβ-40 Y10F Increases βfibrils Formation but Attenuates the Neurotoxicity of Amyloid-β Peptide.
Int J Mol Sci . 2012;13(5):5324-37. (IF 4.556)
12. Gong C, Tao G, Yang L, Liu J, He H, Zhuang Z.
The role of reactive oxygen species in silicon dioxide nanoparticle-induced cytotoxicity and DNAdamage in HaCaT cells.
Mol Biol Rep . 2012 Apr;39(4):4915-25. (IF 1.402)
13. Wang J, Wang Q, Li J, Shen Q, Wang F, Wang L.
Cadmium induces hydrogen peroxide production and initiates hydrogen peroxide-dependentapoptosis in the gill of freshwater crab, Sinopotamon henanense.
COMP BIOCHEM PHYS C . 2012 Nov;156(3-4):195-201. (IF 2.892)
14. Li R, Li H, Luo H, Lin Z, Jiang Z, Luo W.
SSAO inhibitors suppress hepatocellular tumor growth in mice.
Cellular Immunology . 2013 May–June;283(1-2):61–9. (IF 3.291)
15. Wang J, Zhang P, Shen Q, Wang Q, Liu D, Li J, Wang L.
The Effects of Cadmium Exposure on the Oxidative State and Cell Death in the Gill of Freshwater Crab Sinopotamon henanense.
PLoS One . 2013 May 30;8(5):e64020. (IF 2.74)
16. Dong J, Zhang M, Liao Z, Wu W, Wang T, Chen L, Yang T, Guo L, Xu D, Wen F.
Resolvin-D1 inhibits interleukin-8 and hydrogen peroxide production induced by cigarette smoke extract in 16HBE cells via attenuating NF-κB activation.
CHINESE MED J-PEKING . 2014;127(3):511-7. (IF 1.585)
17. Zhang L, Dong L, Liu X, Jiang Y, Zhang L, Zhang X, Li X, Zhang Y.
α-Melanocyte-stimulating hormone protects retinal vascular endothelial cells from oxidative stress and apoptosis in a rat model of diabetes.
PLoS One . 2014 Apr 2;9(4):e93433. (IF 2.74)
18. Meng H, Guo J, Wang H, Yan P, Niu X, Zhang J.
Erythropoietin activates Keap1-Nrf2/ARE pathway in rat brain after ischemia.
Int J Neurosci . 2014 May;124(5):362-8. (IF 2.107)
19. Ren M, He L, Huang Y, Mao Q, Li S, Qu H, Bian M, Liang P, Chen X, Ling J, Chen T, Liang C, Wang X, Li X, Yu X.
Molecular characterization of Clonorchis sinensis secretory myoglobin: delineating its role in anti-oxidative survival.
PARASITE VECTOR . 2014 May 29;7(1):250. (IF 2.824)
20. Liu J, Yin Y, Song Z, Li Y, Jiang S, Shao C, Wang Z.
NADH: flavin oxidoreductase/NADH oxidase and ROS regulate microsclerotium development in Nomuraea rileyi.
WORLD J MICROB BIOT . 2014 Jul;30(7):1927-35. (IF 2.477)
21. Chen H, Gong Y, Han R.
Cadmium Telluride Quantum Dots (CdTe-QDs) and Enhanced Ultraviolet-B (UV-B) Radiation Trigger Antioxidant Enzyme Metabolism and Programmed Cell Death in Wheat Seedlings.
PLoS One . 2014 Oct 20;9(10):e110400. (IF 2.74)
22. Zhang H, Liu Y, Wen F, Yao D, Wang L, Guo J, Ni L, Zhang A, Tan M, Jiang M.
A novel rice C2H2-type zinc finger protein, ZFP36, is a key player involved in abscisic acid-induced antioxidant defence and oxidative stress tolerance in rice.
J Exp Bot . 2014 Nov;65(20):5795-809. (IF 5.908)
23. Zhong S, Zhao L, Li Q, Yang P, Varghese Z, Moorhead JF, Chen Y, Ruan XZ.
Inflammatory Stress Exacerbated Mesangial Foam Cell Formation and Renal Injury via Disrupting Cellular Cholesterol Homeostasis.
Inflammation . 2015;38(3):959-71. (IF 3.212)
24. Li W, Cao L, Han L, Xu Q, Ma Q.
Superoxide dismutase promotes the epithelial-mesenchymal transition of pancreatic cancer cells via activation of the H2O2/ERK/NF-κB axis.
Int J Oncol . 2015;46(6):2613-20. (IF 3.899)
25. Wu F, Sheng P, Tan J, Chen X, Lu G, Ma W, Heng Y, Lin Q, Zhu S, Wang J, Wang J, Guo X, Zhang X, Lei C, Wan J.
Plasma membrane receptor-like kinase leaf panicle 2 acts downstream of the DROUGHT AND SALT TOLERANCE transcription factor to regulate drought sensitivity in rice.
J Exp Bot . 2015 Jan;66(1):271-81. (IF 5.908)
26. Wang W, Ding XQ, Gu TT, Song L, Li JM, Xue QC, Kong LD.
Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377.
FREE RADICAL BIO MED . 2015 Jun;83:214-26. (IF 6.17)
27. Yang HT, Yang MC, Sun JJ, Guo F, Lan JF, Wang XW, Zhao XF, Wang JX.
Catalase eliminates reactive oxygen species and influences the intestinal microbiota of shrimp.
FISH SHELLFISH IMMUN . 2015 Nov;47(1):63-73. (IF 3.298)
28. Wang D, Ma Y, Yang X, Xu X, Zhao Y, Zhu Z, Wang X, Deng H, Li C, Gao F, Tong J, Yamanaka K, An Y.
Hypermethylation of the Keap1 gene inactivates its function, promotes Nrf2 nuclear accumulation, and is involved in arsenite-induced human keratinocyte transformation.
FREE RADICAL BIO MED . 2015 Dec;89:209-19. (IF 6.17)
29. Tang Y, Xu Q, Peng H, Liu Z, Yang T, Yu Z, Cheng G, Li X, Zhang G, Shi R.
The role of vascular peroxidase 1 in ox-LDL-induced vascular smooth muscle cell calcification.
Atherosclerosis . 2015 Dec;243(2):357-63. (IF 3.919)
30. Zhang Z, Huang T, Yu F, Liu X, Zhao C, Chen X, Kelvin DJ, Gu J.
Infectious Progeny of 2009 A (H1N1) Influenza Virus Replicated in and Released from Human Neutrophils.
SCI REP-UK . 2015 Dec 7;5:17809. (IF 3.998)
31. Zhang Y, Zhang Y.
Toll-like receptor-6 (TLR6) deficient mice are protected from myocardial fibrosis induced by high fructose feeding through anti-oxidant and inflammatory signaling pathway.
BIOCHEM BIOPH RES CO . 2016 Apr 29;473(2):388-95. (IF 2.985)
32. Shen Y, Miao NJ, Xu JL, Gan XX, Xu D, Zhou L, Xue H, Zhang W, Lu LM.
N-acetylcysteine alleviates angiotensin II-mediated renal fibrosis in mouse obstructed kidneys.
Acta Pharmacol Sin . 2016 May;37(5):637-44. (IF 5.064)
33. Ren H, Yang Z, Luo C, Zeng H, Li P, Kang JX, Wan JB, He C, Su H.
Enriched Endogenous Omega-3 Fatty Acids in Mice Ameliorate Parenchymal Cell Death After TraumaticBrain Injury.
Mol Neurobiol . 2016 May 11.[Epub ahead of print] (IF 4.5)
34. Shen J, Tian Y, Li Y, Ma R, Zhang Q, Zhang J, Fang J.
Bactericidal Effects against S. aureus and Physicochemical Properties of Plasma Activated Water stored atdifferent temperatures.
SCI REP-UK . 2016 Jun 27;6:28505. (IF 3.998)
35. Yang HT, Yang MC, Sun JJ, Shi XZ, Zhao XF, Wang JX.
Dual oxidases participate in the regulation of intestinal microbiotic homeostasis in the
Dev Comp Immunol . 2016 Jun;59:153-63. (IF 3.192)
36. Yang L, Yuan Y, Fu C, Xu X, Zhou J, Wang S, Kong L, Li Z, Guo Q, Wei L.
LZ-10, a novel analog of enoxacin, inducing apoptosis via activation of
FREE RADICAL BIO MED . 2016 Jun;95:155-68. (IF 6.17)
37. Wu B, Yu H, Wang Y, Pan Z, Zhang Y, Li T, Li L, Zhang W, Ge L, Chen Y, Ho CK, Zhu D, Huang X, Lou Y.
Peroxiredoxin-2 nitrosylation facilitates cardiomyogenesis of mouse embryonic stem cells via XBP-1s/PI3Kpathway.
FREE RADICAL BIO MED . 2016 Aug;97:179-91. (IF 6.17)
38. Zhu Z, Sun B, Xu X, Chen H, Zou L, Chen G, Cao B, Chen C, Lei J.
Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Droughtand Osmotic Stress Tolerance.
Front Plant Sci . 2016 Aug 30;7:1285. (IF 4.402)
39. Wang Q, Zhou Y, Chen K, Ju X.
Identification and characterization of an atypical 2-cys peroxiredoxin from the silkworm, Bombyx mori.
Insect Mol Biol . 2016 Aug;25(4):347-54. (IF 2.533)
40. Li H, Sun JJ, Chen GY, Wang WW, Xie ZT, Tang GF, Wei SD.
Carnosic acid nanoparticles suppress liver ischemia/reperfusion injury by inhibition of ROS, Caspases and NF-κB signaling pathway in mice.
Biomed Pharmacother . 2016 Aug;82:237-46. (IF 4.545)
41. Huang Q, Wang Q, Zhang S, Jiang S, Zhao L, Yu L, Hultström M, Patzak A, Li L, Wilcox CS, Lai EY.
Increased hydrogen peroxide impairs angiotensin II contractions of afferent arterioles in mice after renalischaemia-reperfusion injury.
ACTA PHYSIOL . 2016 Oct;218(2):136-45. (IF 5.542)
42. Li K, Xie Y, You M, Huang L, Zheng X.
Cerium Oxide-Incorporated Calcium Silicate Coating Protects MC3T3-E1 Osteoblastic Cells from H2O2-Induced Oxidative Stress.
Biol Trace Elem Res . 2016 Nov;174(1):198-207. (IF 2.639)
43. Wang SQ, Wang C, Chang LM, Zhou KR, Wang JW, Ke Y, Yang DX, Shi HG, Wang R, Shi XL, Ma LY, Liu HM.
Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathway.
ONCOTARGET . 2016 Nov 8;7(45):72990-73002. (IF 5.168)
44. Liu Q, Yang J, Yan S, Zhang S, Zhao J, Wang W, Yang T, Wang X, Mao X, Dong J, Zhu X, Liu B.
The germin-like protein OsGLP2-1 enhances resistance to fungal blast and bacterial blight in
Plant Mol Biol . 2016 Nov;92(4-5):411-423. (IF 3.302)
45. Xu ZQ, Shao BZ, Ke P, Liu JG, Liu GK, Chen XW, Su DF, Liu C.
Combined administration of anisodamine and neostigmine rescued acute lethal crush syndrome through α7nAChR-dependent JAK2-STAT3 signaling.
SCI REP-UK . 2016 Nov 22;6:37709. (IF 3.998)
46. Zhou B, Mu J, Gong Y, Lu C, Zhao Y, He T, Qin Z.
Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4expression.
Redox Biol . 2016 Dec 30;11:390-402. (IF 9.986)
47. Zhang Y, Huang X, Zhao XY, Hu YJ, Sun HY, Kong WJ.
Role ofthe Ubiquitin C-Terminal Hydrolase L1-Modulated Ubiquitin Proteasome System in Auditory Cortex Senescence.
ORL J OTO-RHINO-LARY . 2017;79(3):153-163. (IF 1.08)
48. Liu X, Zhang X, Ding Y, Zhou W, Tao L, Lu P, Wang Y, Hu R.
Nuclear Factor E2-Related Factor-2 Negatively Regulates NLRP3 Inflammasome Activity by InhibitingReactive Oxygen Species-Induced NLRP3 Priming.
ANTIOXID REDOX SIGN . 2017 Jan 1;26(1):28-43. (IF 6.323)
49. Zhong S, Zhao L, Wang Y, Zhang C, Liu J, Wang P, Zhou W, Yang P, Varghese Z, Moorhead JF, Chen Y, Ruan XZ.
Cluster of Differentiation 36 Deficiency Aggravates Macrophage Infiltration and Hepatic Inflammation byUpregulating Monocyte Chemotactic Protein-1 Expression of Hepatocytes Through Histone Deacetylase 2-Dependent Pathway.
ANTIOXID REDOX SIGN . 2017 Jan 10.doi: 10.1089/ars.2016.6808. [Epub ahead of print] (IF 6.323)
50. Chen Z, Xie X, Huang J, Gong W, Zhu X, Chen Q, Huang J, Huang H.
Connexin43 regulates high glucose-induced expression of fibronectin, ICAM-1 and TGF-β1 via Nrf2/AREpathway in glomerular mesangial cells.
FREE RADICAL BIO MED . 2017 Jan;102:77-86. (IF 6.17)
51. Dong W, Liu Z, Qiu L, Wang W, Song X, Wang X, Li Y, Xin L, Wang L, Song L.
The modulation role of serotonin in Pacific oyster Crassostrea gigas in response to air exposure.
FISH SHELLFISH IMMUN . 2017 Jan 31. pii: S1050-4648(17)30056-6. (IF 3.298)
52. Zhang H, Chen MK, Li K, Hu C, Lu MH, Situ J.
Eupafolin nanoparticle improves acute renal injury induced by LPS through inhibiting ROS andinflammation.
Biomed Pharmacother . 2017 Jan;85:704-711. (IF 4.545)
53. Lu XL, Zhao CH, Yao XL, Zhang H.
Quercetin attenuates high fructose feeding-induced atherosclerosis by suppressing inflammation andapoptosis via ROS-regulated PI3K/AKT signaling pathway.
Biomed Pharmacother . 2017 Jan;85:658-671. (IF 4.545)
54. Jiang DQ, Wang Y, Li MX, Ma YJ, Wang Y.
SIRT3 in Neural Stem Cells Attenuates Microglia Activation-Induced Oxidative Stress Injury Through Mitochondrial Pathway.
Front Cell Neurosci . 2017 Jan 31;11:7. (IF 3.921)
55. Chen Z, Xie X, Huang J, Gong W, Zhu X, Chen Q, Huang J, Huang H.
Connexin43 regulates high glucose-induced expression of fibronectin, ICAM-1 andTGF-β1 viaNrf2/ARE pathway in glomerular mesangial cells.
FREE RADICAL BIO MED 2017 Jan;102:77-86. (IF 6.17)
56. Ma Y, Jiao J, Fan X, Sun H, Zhang Y, Jiang J, Liu C.
Endophytic Bacterium Pseudomonas fluorescens RG11 May Transform Tryptophan to Melatonin and Promote Endogenous Melatonin Levels in the Roots of Four Grape Cultivars.
Front Plant Sci . 2017 Jan 10;7:2068. (IF 4.402)
57. Zhang H, Chen MK, Li K, Hu C, Lu MH, Situ J.
Eupafolin nanoparticle improves acute renal injury induced by LPS through inhibiting ROS and inflammation.
Biomed Pharmacother . 2017 Jan;85:704-711. (IF 4.545)
58. Lu XL, Zhao CH, Yao XL, Zhang H.
Quercetin attenuates high fructose feeding-induced atherosclerosis by suppressing inflammation and apoptosis via ROS-regulated PI3K/AKT signaling pathway.
Biomed Pharmacother . 2017 Jan;85:658-671. (IF 4.545)
59. Zhu Z, Chen Y, Shi G, Zhang X.
Selenium delays tomato fruit ripening by inhibiting ethylene biosynthesis and enhancing the antioxidantdefense system.
Food Chem . 2017 Mar 15;219:179-184. (IF 6.306)
60. Zhu Z, Chen Y, Shi G, Zhang X.
Selenium delays tomato fruit ripening by inhibiting ethylene biosynthesis and enhancing the antioxidant defense system.
Food Chem . 2017 Mar 15;219:179-184. (IF 6.306)
61. Dai F, Li Q, Wang Y, Ge C, Feng C, Xie S, He H, Xu X, Wang C.
Design, Synthesis,and Biological Evaluation of Mitochondria-Targeted Flavone-Naphthalimide-Polyamine Conjugates with Antimetastatic Activity.
J Med Chem . 2017 Mar 9;60(5):2071-2083. (IF 6.205)
62. Xie Y, Han S, Li X, Amombo E, Fu J.
Amelioration of Salt Stress on Bermudagrass by the Fungus Aspergillus aculeatus.
MOL PLANT MICROBE IN . 2017 Mar;30(3):245-254. (IF 3.696)
63. Gong W, Li J, Chen Z, Huang J, Chen Q, Cai W, Liu P, Huang H.
Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys.
FREE RADICAL BIO MED . 2017 May;106:393-405. (IF 6.17)
64. Yao W, Zhao H, Shi R, Li X, Li Y, Ke C, Liu J.
Recombinant protein transduction domain-Cu/Zn superoxide dismutase alleviates bone cancerpain via peroxiredoxin 4 modulation and antioxidation.
BIOCHEM BIOPH RES CO . 2017 May 13;486(4):1143-1148. (IF 2.985)
65. Chen J, Wang YX, Dong MQ, Zhang B, Luo Y, Niu W, Li ZC.
Reoxygenation Reverses Hypoxic Pulmonary Arterial Remodeling by Inducing Smooth MuscleCell Apoptosis via Reactive Oxygen Species-Mediated Mitochondrial Dysfunction.
J Am Heart Assoc . 2017 Jun 23;6(6). (IF 4.605)
66. Wei G, Lai Y, Wang G, Chen H, Li F, Wang S.
Insect pathogenic fungus interacts with the gut microbiota to accelerate mosquito mortality.
P NATL ACAD SCI USA . 2017 Jun 6;114(23):5994-5999. (IF 9.412)
67. Chen YH, Liu SJ, Gao MM, Zeng T, Lin GW, Tan NN, Tang HL, Lu P, Su T, Sun WW, Xie LC, Yi YH, Long YS.
MDH2 isan RNA binding protein involved in downregulation of sodium channel Scn1aexpression under seizure condition.
BBA-BIOMEMBRANES . 2017 Jun;1863(6):1492-1499. (IF 3.411)
68. Zhu Z, Ren Z, Fan X, Pan Y, Lv S, Pan C, Lei A, Zeng W.
Cysteine protects rabbit spermatozoa against reactive oxygen species-induced damages.
PLoS One . 2017 Jul 10;12(7):e0181110. (IF 2.74)
69. Wang B, Xiong S, Lin S, Xia W, Li Q, Zhao Z, Wei X, Lu Z, Wei X, Gao P, Liu D, Zhu Z.
Enhanced Mitochondrial Transient Receptor Potential Channel, Canonical Type 3-MediatedCalcium Handling in the Vasculature From Hypertensive Rats.
J Am Heart Assoc . 2017 Jul 15;6(7). pii: e005812. (IF 4.605)
70. Liu Z, Liu Y, Xu Q, Peng H, Tang Y, Yang T, Yu Z, Cheng G, Zhang G, Shi R.
Critical role of vascular peroxidase 1 in regulating endothelial nitric oxide synthase.
Redox Biol . 2017 Aug;12:226-232. (IF 9.986)
71. Meng W, Pei Z, Feng Y, Zhao J, Chen Y, Shi W, Xu Q, Lin F, Sun M, Xiao K.
Neglected role of hydrogen sulfide in sulfur mustard poisoning: Keap1 S-sulfhydration and subsequent Nrf2 pathway activation.
SCI REP-UK . 2017 Aug 25;7(1):9433. (IF 3.998)
72. Zhong S, Zhao L, Wang Y, Zhang C, Liu J, Wang P, Zhou W, Yang P, Varghese Z, Moorhead JF, Chen Y, Ruan XZ.
Cluster of Differentiation 36 Deficiency Aggravates Macrophage Infiltration and HepaticInflammation by Upregulating Monocyte Chemotactic Protein-1 Expression of Hepatocytes Through Histone Deacetylase 2-Dependent Pathway.
ANTIOXID REDOX SIGN . 2017 Aug 1;27(4):201-214. (IF 6.323)
73. Tang S, Li L, Wang Y, Chen Q, Zhang W, Jia G, Zhi H, Zhao B, Diao X.
Genotype-specific physiological and transcriptomic responses to drought stress in Setaria italica (an emerging model for Panicoideae grasses).
SCI REP-UK . 2017 Aug 30;7(1):10009. (IF 3.998)
74. Lv Y, Cheng X, Du G, Zhou J, Chen J.
Engineering of an H2O2 auto-scavenging in vivo cascade for pinoresinol production.
Biotechnol Bioeng . 2017 Sep;114(9):2066-2074. (IF 4.002)
75. Li X, Han S, Wang G, Liu X, Amombo E, Xie Y, Fu J.
The Fungus Aspergillus aculeatus Enhances Salt-Stress Tolerance, Metabolite Accumulation, and Improves Forage Quality in Perennial Ryegrass.
Front Microbiol . 2017 Sep 4;8:1664. (IF 4.235)
76. Lv Y,Cheng X,Du G,Zhou J,Chen J
Engineering of an H2 O2 auto-scavenging in vivo cascade for pinoresinol production.
Biotechnol Bioeng . 2017 Sep;114(9):2066-2074. (IF 4.002)
77. Luo X, Dan Wang, Luo X, Zhu X, Wang G, Ning Z, Li Y, Ma X, Yang R, Jin S, Huang Y, Meng Y, Li X.
Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liversinusoidal endothelial cells defenestration.
Redox Biol . 2017 Oct;13:508-521. (IF 9.986)
78. Tang G, Zhang C, Ju Z, Zheng S, Wen Z, Xu S, Chen Y, Ma Z.
The mitochondrial membrane protein FgLetm1 regulates mitochondrial integrity, production of endogenous reactive oxygen species and mycotoxin biosynthesis in Fusarium graminearum.
Mol Plant Pathol . 2017 Oct 27. (IF 4.326)
79. Zou Y, Xiong JB, Ma K, Wang AZ, Qian KJ.
Rac2 deficiency attenuates CCl4-induced liver injury through suppressing inflammation and oxidative stress.
Biomed Pharmacother . 2017 Oct;94:140-149. (IF 4.545)
80. Meng M.
Digitoflavone (DG) attenuates LPS-induced acute lung injury through reducing oxidative stress and inflammatory response dependent on the suppression of TXNIP/NLRP3 and NF-κB.
Biomed Pharmacother . 2017 Oct;94:712-725. (IF 4.545)
81. Liu M, Du G, Liu B, Hu Y, Liu J, Jia Y, Minion FC, Shao G, Zhao R.
Cholesterol exacerbates Mycoplasma hyopneumoniae-induced apoptosis via stimulatingproliferation and adhesion to porcine alveolar macrophages.
Vet Microbiol . 2017 Nov;211:112-118. (IF 3.03)
82. Yang HT, Zou SS, Zhai LJ, Wang Y, Zhang FM, An LG, Yang GW.
Pathogen invasion changes the intestinal microbiota composition and induces innate immuneresponses in the zebrafish intestine.
FISH SHELLFISH IMMUN . 2017 Dec;71:35-42. (IF 3.298)
83. Ma J, Chen J, Wang M, Ren Y, Wang S, Lei C, Cheng Z, Sodmergen.
Disruption of OsSEC3A increases the content of salicylicacid and induces plant defenseresponses in rice.
J Exp Bot . 2017 Dec 30. (IF 5.908)
84. Li Y, Pan J, Ye G, Zhang Q, Wang J, Zhang J, Fang J.
In vitro studies ofthe antimicrobial effect of non-thermal plasma-activated water asa novelmouthwash.
Eur J Oral Sci . 2017 Dec;125(6):463-470. (IF 2.22)
85. Xu S, Yang X, Qian Y, Xiao Q.
Parkinson disease-related DJ-1 modulates the expression of uncoupling protein 4 againstoxidative stress.
J Neurochem . 2018 Jan 8. (IF 4.066)
86. Zhang L,Wang J,Chen Y,Zeng L,Li Q,Liu Y,Wang L
Thioredoxin-1 Protects Bone Marrow-Derived Mesenchymal Stromal Cells from Hyperoxia-Induced Injury In Vitro.
Oxid Med Cell Longev . 2018 Jan 21;2018:1023025. (IF 5.076)
87. Su X, Tian Y, Zhou H, Li Y, Zhang Z, Jiang B, Yang B, Zhang J, Fang J.
Inactivation efficacy of non-thermal plasma activated solutions against Newcastle disease virus.
APPL ENVIRON MICROB . 2018 Feb 23. (IF 4.016)
88. Qu C, Li J, Zhou Y, Yang S, Chen W, Li F, You B, Liu Y, Zhang X.
Targeted Delivery of Doxorubicin via CD147-Mediated ROS/pH Dual-Sensitive Nanomicelles for the Efficient Therapy of Hepatocellular Carcinoma.
AAPS J . 2018 Feb 23;20(2):34. (IF 3.737)
89. Gong W, Chen Z, Zou Y, Zhang L, Huang J, Liu P, Huang H.
CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys.
FREE RADICAL BIO MED . 2018 Feb 1;115:338-350. (IF 6.17)
90. Liao X, Li J, Muhammad AI, Suo Y, Chen S, Ye X, Liu D, Ding T.
Application ofa Dielectric Barrier Discharge Atmospheric Cold Plasma (Dbd-Acp)for EshcerichiaColi Inactivation in Apple Juice.
J Food Sci . 2018 Feb;83(2):401-408. (IF 2.478)
91. Zhang XT,Sun XQ,Wu C,Chen JL,Yuan JJ,Pang QF,Wang ZP
Heme oxygnease-1 induction by methylene blue protects RAW264.7 cells from hydrogen peroxide-induced injury.
Biochem Pharmacol . 2018 Feb;148:265-277. (IF 4.96)
92. Liao X,Li J,Muhammad AI,Suo Y,Chen S,Ye X,Liu D,Ding T
Application of a Dielectric Barrier Discharge Atmospheric Cold Plasma (Dbd-Acp) for Eshcerichia Coli Inactivation in Apple Juice.
J Food Sci . 2018 Feb;83(2):401-408. (IF 2.478)
93. Li W, Jiang Z, Xiao X, Wang Z, Wu Z, Ma Q, Cao L.
Curcumin inhibits superoxide dismutase-induced epithelial-to-mesenchymal transition via the PI3K/Akt/NF-κB pathway in pancreatic cancer cells.
Int J Oncol . 2018 Mar 1. (IF 3.899)
94. Qiu M,Shi F,Dai F,Song R,Wang S,You Y,Zhao B
A reactive oxygen species activation mechanism contributes to Sophoridine-induced apoptosis in rat liver BRL-3A cells.
J Ethnopharmacol . 2018 Mar 1;213:376-383. (IF 3.69)
95. Zang Y,Liu J,Tang XX,Zhou B
Description of a Zostera marina catalase gene involved in responses to temperature stress.
PeerJ . 2018 Mar 26;6:e4532. (IF 2.379)
96. Zhou S,Hong Q,Li Y,Li Q,Wang M
Autophagy contributes to regulate the ROS levels and PCD progress in TMV-infected tomatoes.
Plant Sci . 2018 Apr;269:12-19. (IF 3.591)
97. Liu S,Zhang C,Chao N,Lu J,Zhang Y
Cloning, Characterization, and Functional Investigation of VaHAESA from Vitis amurensis Inoculated with Plasmopara viticola.
Int J Mol Sci . 2018 Apr 16;19(4). pii: E1204. (IF 4.556)
98. Su X,Tian Y,Zhou H,Li Y,Zhang Z,Jiang B,Yang B,Zhang J,Fang J
Inactivation Efficacy of Nonthermal Plasma-Activated Solutions against Newcastle Disease Virus.
APPL ENVIRON MICROB . 2018 Apr 16;84(9). pii: e02836-17. (IF 4.016)
99. Huang L, Zhang M, Jia J, Zhao X, Huang X, Ji E, Ni L, Jiang M.
An Atypical Late Embryogenesis Abundant Protein OsLEA5 Plays A Positive Role In ABA-Induced Antioxidant Defense In Oryza Sativa L.
Plant Cell Physiol. . 2018 May 1;59(5):916-929
100. Xu S,Yang X,Qian Y,Xiao Q
Parkinson’s disease-related DJ-1 modulates the expression of uncoupling protein 4 against oxidative stress.
J Neurochem . 2018 May;145(4):312-322. (IF 4.066)
101. Li Y,Li Q,Hong Q,Lin Y,Mao W,Zhou S
Reactive oxygen species triggering systemic programmed cell death process via elevation of nuclear calcium ion level in tomatoes resisting tobacco mosaic virus.
Plant Sci . 2018 May;270:166-175. (IF 3.591)
102. Zhu J,Sun Y,Lu Y,Jiang X,Ma B,Yu L,Zhang J,Dong X,Zhang Q
Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nuclear translocation via regulating PI3K/Akt pathway.
Cell Death Dis . 2018 Jun 13;9(6):708. (IF 6.304)
103. Leng Y,Wu Y,Lei S,Zhou B,Qiu Z,Wang K,Xia Z
Inhibition of HDAC6 Activity Alleviates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats: Potential Role of Peroxiredoxin 1 Acetylation and Redox Regulation.
Oxid Med Cell Longev . 2018 Jun 25;2018:9494052. (IF 5.076)
104. Zhang Y,Li Q,Fang M,Ma Y,Liu N,Yan X,Zhou J,Li F
The Kidney Injury Induced by Short-Term PM2.5 Exposure and the Prophylactic Treatment of Essential Oils in BALB/c Mice.
Oxid Med Cell Longev . 2018 Jul 29;2018:9098627. (IF 5.076)
105. Citao Liu,Shujun Ou,Bigang Mao,Jiuyou Tang,Wei Wang,Hongru Wang,Shouyun Cao,Michael R Schläppi,Bingran Zhao,Guoying Xiao,Xiping Wang,Chengcai Chu
Early Selection of bZIP73 Facilitated Adaptation of Japonica Rice to Cold Climates
Nat Commun. 2018 Aug 17;9(1):3302.;doi: 10.1038/s41467-018-05753-w. (IF 12.121)
106. Yin Y,Wang Z,Cheng D,Chen X,Chen Y,Ma Z
The ATP-binding protein FgArb1 is essential for penetration, infectious and normal growth of Fusarium graminearum.
New Phytol . 2018 Sep;219(4):1447-1466. (IF 8.512)
107. Han X,Wu YC,Meng M,Sun QS,Gao SM,Sun H
Linarin prevents LPS‑induced acute lung injury by suppressing oxidative stress and inflammation via inhibition of TXNIP/NLRP3 and NF‑κB pathways.
Int J Mol Med . 2018 Sep;42(3):1460-1472. (IF 3.098)
108. Yin Y,Wu S,Chui C,Ma T,Jiang H,Hahn M,Ma Z
The MAPK kinase BcMkk1 suppresses oxalic acid biosynthesis via impeding phosphorylation of BcRim15 by BcSch9 in Botrytis cinerea.
PLoS Pathog . 2018 Sep 13;14(9):e1007285. (IF 6.218)
109. Wang L,Gao H,Yang X,Liang X,Tan Q,Chen Z,Zhao C,Gu Z,Yu M,Zheng Y,Huang Y,Zhu L,Jacob TJC,Wang L,Chen L
The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation.
CLIN EXP PHARMACOL P . 2018 Oct;45(10):1019-1027. (IF 2.092)
110. Li J,Ma L,Liao X,Liu D,Lu X,Chen S,Ye X,Ding T
Ultrasound-Induced Escherichia coli O157:H7 Cell Death Exhibits Physical Disruption and Biochemical Apoptosis.
Front Microbiol . 2018 Oct 16;9:2486. (IF 4.235)
111. Yu Z,Dong L,Jiang Z,Yi K,Zhang J,Zhang Z,Zhu Z,Wu Y,Xu M,Ni J
A semi-dominant mutation in a CC-NB-LRR-type protein leads to a short-root phenotype in rice.
Rice (N Y) . 2018 Oct 3;11(1):54.
112. Jin Y,Yang Q,Liang L,Ding L,Liang Y,Zhang D,Wu B,Yang T,Liu H,Huang T,Shen H,Tu H,Pan Y,Wei Y,Yang Y,Zhou F
Compound kushen injection suppresses human acute myeloid leukaemia by regulating the Prdxs/ROS/Trx1 signalling pathway.
J EXP CLIN CANC RES . 2018 Nov 19;37(1):277. (IF 7.068)
113. Deng W,Duan M,Qian B,Zhu Y,Lin J,Zheng L,Zhang C,Qi X,Luo M
NADPH oxidase 1/4 inhibition attenuates the portal hypertensive syndrome via modulation of mesenteric angiogenesis and arterial hyporeactivity in rats.
CLIN RES HEPATOL GAS . 2018 Nov 6. pii: S2210-7401(18)30220-1. (IF 2.718)
114. Meng Q,Xu J,Liang C,Liu J,Hua J,Zhang Y,Ni Q,Shi S,Yu X
GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation.
Cell Death Dis . 2018 Dec 11;9(12):1187. (IF 6.304)
115. Liang F,Su F,Wang X,Long S,Zheng Y,He X,Pang J,Pei Z
Xyloketal derivative C53N protects against mild traumatic brain injury in mice.
DRUG DES DEV THER. 2018 Dec 27;13:173-182. (IF 3.216)
116. Zhou R,Wang H,Yang Y,Zhang C,Dong X,Du J,Yan L,Zhang G,Gu Z,Zhao Y
Tumor microenvironment-manipulated radiocatalytic sensitizer based on bismuth heteropolytungstate for radiotherapy enhancement.
Biomaterials. 2019 Jan;189:11-22. (IF 10.317)
117. Zeng SY,Yang L,Yan QJ,Gao L,Lu HQ,Yan PK
Nox1/4 dual inhibitor GKT137831 attenuates hypertensive cardiac remodelling associating with the inhibition of ADAM17-dependent proinflammatory cytokines-induced signalling pathways in the rats with a
Biomed Pharmacother. 2019 Jan;109:1907-1914. (IF 4.545)
118. Zhang L,Zhao P,Yue C,Jin Z,Liu Q,Du X,He Q
Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer’s disease.
Biomaterials. 2019 Mar;197:393-404. (IF 10.317)
119. You Y,Huang Y,Wang D,Li Y,Wang G,Jin S,Zhu X,Wu B,Du X,Li X
Angiotensin (1-7) inhibits arecoline-induced migration and collagen synthesis in human oral myofibroblasts via inhibiting NLRP3 inflammasome activation.
J Cell Physiol. 2019 Apr;234(4):4668-4680. (IF 5.546)
120. Xin L,Huang B,Zhang H,Li C,Bai C,Wang C
OsHV-1 infection leads to mollusc tissue lesion and iron redistribution, revealing a strategy of iron limitation against pathogen.
Metallomics. 2019 Apr 17;11(4):822-832. (IF 3.796)
121. Du X,Zhang T,Ma G,Gu X,Wang G,Li J
Glucose-responsive mesoporous silica nanoparticles to generation of hydrogen peroxide for synergistic cancer starvation and chemistry therapy.
INT J NANOMED. 2019 Apr 2;14:2233-2251. (IF 5.115)
122. Chen C,Jiang X,Li Y,Yu H,Li S,Zhang Z,Xu H,Yang Y,Liu G,Zhu F,Ren X,Zou L,Xu B,Liu J,Spencer PS,Yang X
Low-dose oral copper treatment changes the hippocampal phosphoproteomic profile and perturbs mitochondrial function in a mouse model of Alzheimer’s disease.
FREE RADICAL BIO MED. 2019 May 1;135:144-156. (IF 6.17)
123. Zhong J,Xie J,Xiao J,Li D,Xu B,Wang X,Wen H,Zhou Z,Cheng Y,Xu J,Wang H
Inhibition of PDE4 by FCPR16 induces AMPK-dependent autophagy and confers neuroprotection in SH-SY5Y cells and neurons exposed to MPP+-induced oxidative insult.
FREE RADICAL BIO MED. 2019 May 1;135:87-101. (IF 6.17)
124. Liao X,Liu D,Chen S,Ye X,Ding T
Degradation of antibiotic resistance contaminants in wastewater by atmospheric cold plasma: kinetics and mechanisms.
Environ Technol. 2019 May 27:1-14; (IF 2.213)
125. Han D,Gu X,Gao J,Wang Z,Liu G,Barkema HW,Han B
Chlorogenic acid promotes the Nrf2/HO-1 anti-oxidative pathway by activating p21Waf1/Cip1 to resist dexamethasone-induced apoptosis in osteoblastic cells.
FREE RADICAL BIO MED. 2019 Jun;137:1-12. (IF 6.17)
126. Zeng SY,Yang L,Lu HQ,Yan QJ,Gao L,Qin XP
Rutaecarpine prevents hypertensive cardiac hypertrophy involving the inhibition of Nox4-ROS-ADAM17 pathway.
J Cell Mol Med. 2019 Jun;23(6):4196-4207. (IF 4.486)
127. Tang Y,Huang Q,Liu C,Ou H,Huang D,Peng F,Liu C,Mo Z
p22phox promotes Ang-II-induced vascular smooth muscle cell phenotypic switch by regulating KLF4 expression.
BIOCHEM BIOPH RES CO. 2019 Jun 18;514(1):280-286. (IF 2.985)
128. Gong F,Gao L,Ding T
IDH2 protects against nonalcoholic steatohepatitis by alleviating dyslipidemia regulated by oxidative stress.
BIOCHEM BIOPH RES CO. 2019 Jun 30;514(3):593-600. (IF 2.985)
129. Wu Y,Guo T,Qiu Y,Lin Y,Yao Y,Lian W,Lin L,Song J,Yang H
An inorganic prodrug, tellurium nanowires with enhanced ROS generation and GSH depletion for selective cancer therapy.
Chem Sci. 2019 Jun 6;10(29):7068-7075. (IF 9.346)
130. Zhang P,Wang XL,Yang ZH,Su XJ,Wang XH
A novel rat model of seminal vesiculitis.
Asian J Androl. 2019 Jul-Aug;21(4):360-364. (IF 2.448)
131. Yang N,Ma H,Jiang Z,Niu L,Zhang X,Liu Y,Wang Y,Cheng S,Deng Y,Qi H,Wang Z
Dosing depending on SIRT3 activity attenuates doxorubicin-induced cardiotoxicity via elevated tolerance against mitochondrial dysfunction and oxidative stress.
BIOCHEM BIOPH RES CO. 2019 Sep 10;517(1):111-117. (IF 2.985)
132. Zhou TJ,Xing L,Fan YT,Cui PF,Jiang HL
Inhibition of breast cancer proliferation and metastasis by strengthening host immunity with a prolonged oxygen-generating phototherapy hydrogel.
J Control Release. 2019 Sep 10;309:82-93. (IF 7.727)
133. Hu JJ,Liu MD,Gao F,Chen Y,Peng SY,Li ZH,Cheng H,Zhang XZ
Photo-controlled liquid metal nanoparticle-enzyme for starvation/photothermal therapy of tumor by win-win cooperation.
Biomaterials. 2019 Oct;217:119303. (IF 10.317)
134. Zhou G,Wang YS,Peng H,Shen PF,Xie XB,Shi QS
Functional roles of norCB in Pseudomonas aeruginosa ATCC 9027 under aerobic conditions.
J BASIC MICROB. 2019 Nov;59(11):1154-1162. (IF 1.909)
135. Tian Z,Yang K,Yao T,Li X,Ma Y,Qu C,Qu X,Xu Y,Guo Y,Qu Y
Catalytically Selective Chemotherapy from Tumor-Metabolic Generated Lactic Acid.
Small. 2019 Nov;15(46):e1903746. (IF 11.459)
136. Jun Tong,Yuanmeng Jin,Qinjie Weng,Shuwen Yu,Hafiz Muhammad Jafar Hussain,Hong Ren,Jing Xu,Wen Zhang,Xiao Li,Weiming Wang,Jingyuan Xie,Nan Chen
Glomerular Transcriptome Profiles in Focal Glomerulosclerosis: New Genes and Pathways for Steroid Resistance
Am J Nephrol. 2020;51(6):442-452.;doi: 10.1159/000505956.
137. Huiying Zhang,Xin Liu,Xiyong Zhang,Ningning Qin,Kaifang Xu,Weihua Yin,Yueqin Zheng,Yuanyuan Song,Rensen Zeng,Jian Liu
Phosphoinositide 3-Kinase Promotes Oxidative Burst, Stomatal Closure and Plant Immunity in Bacterial Invasion
Front Plant Sci. 2020 Jan 24;10:1740.;doi: 10.3389/fpls.2019.01740.
138. Yongjian Guo,Libin Wei,Yuxin Zhou,Na Lu,Xiaoqing Tang,Zhiyu Li,Xiaotang Wang
Flavonoid GL-V9 induces apoptosis and inhibits glycolysis of breast cancer via disrupting GSK-3β-modulated mitochondrial binding of HKII
Free Radic Biol Med. 2020 Jan;146:119-129.;doi: 10.1016/j.freeradbiomed.2019.10.413.
139. Yang X,Zhao H,Luo C,Du L,Cheng J,Xie J,Jiang D,Fu Y
CmAim24 Is Essential for Mitochondrial Morphology, Conidiogenesis, and Mycoparasitism in Coniothyrium minitans.
APPL ENVIRON MICROB. 2020 Feb 18;86(5). pii: e02291-19. (IF 4.016)
140. Xinyu Liao,Donghong Liu,Tian Ding
Nonthermal Plasma Induces the Viable-but-Nonculturable State in Staphylococcus aureus via Metabolic Suppression and the Oxidative Stress Response
Appl Environ Microbiol. 2020 Feb 18;86(5):e02216-19.;doi: 10.1128/AEM.02216-19.
141. Rongrong Ni,Guojing Song,Xiaohong Fu,Ruifeng Song,Lanlan Li,Wendan Pu,Jining Gao,Jun Hu,Qin Liu,Fengtian He,Dinglin Zhang,Gang Huang
Reactive oxygen species-responsive dexamethasone-loaded nanoparticles for targeted treatment of rheumatoid arthritis via suppressing the iRhom2/TNF-α/BAFF signaling pathway
Biomaterials. 2020 Feb;232:119730.;doi: 10.1016/j.biomaterials.2019.119730.
142. Yu Zhang,Liming Li,Jiafu Mu,Jiachen Chen,Shiqing Feng,Jianqing Gao
Implantation of a functional TEMPO-hydrogel induces recovery from rat spinal cord transection through promoting nerve regeneration and protecting bladder tissue
Biomater Sci. 2020 Mar 17;8(6):1695-1701.;doi: 10.1039/c9bm01530b.
143. Yuanyang Dong,Qihang Hou,Jiaqi Lei,Patricia G Wolf,Hammed Ayansola,Bingkun Zhang
Quercetin Alleviates Intestinal Oxidative Damage Induced by H 2 O 2 via Modulation of GSH: In Vitro Screening and In Vivo Evaluation in a Colitis Model of Mice
ACS Omega. 2020 Apr 2;5(14):8334-8346.;doi: 10.1021/acsomega.0c00804.
144. Syed Adeel Zafar,Amjad Hameed,Muhammad Ashraf,Abdus Salam Khan,Zia-Ul- Qamar,Xueyong Li,Kadambot H M Siddique
Agronomic, physiological and molecular characterisation of rice mutants revealed the key role of reactive oxygen species and catalase in high-temperature stress tolerance
Funct Plant Biol. 2020 Apr;47(5):440-453.;doi: 10.1071/FP19246.
145. Boya Zhang,Shiyu Wan,Xinyu Peng,Mingying Zhao,Sai Li,Yuji Pu,Bin He
Human serum albumin-based doxorubicin prodrug nanoparticles with tumor pH-responsive aggregation-enhanced retention and reduced cardiotoxicity
J Mater Chem B. 2020 May 6;8(17):3939-3948.;doi: 10.1039/d0tb00327a.
146. Xue-Jun Chen,Lei Wang,Xiao-Yang Song
Mitoquinone alleviates vincristine-induced neuropathic pain through inhibiting oxidative stress and apoptosis via the improvement of mitochondrial dysfunction
Biomed Pharmacother. 2020 May;125:110003.;doi: 10.1016/j.biopha.2020.110003.
147. Juan Wu,Nan Zhang,Ziguang Liu,Shengyi Liu,Chunxiao Liu,Jianhui Lin,He Yang,Shuang Li,Yasushi Yukawa
The AtGSTU7 gene influences glutathione-dependent seed germination under ABA and osmotic stress in Arabidopsis
Biochem Biophys Res Commun. 2020 Jul 30;528(3):538-544.;doi: 10.1016/j.bbrc.2020.05.153.
148. Ruilong Li,Weidong Yang
Gomisin J inhibits the glioma progression by inducing apoptosis and reducing HKII-regulated glycolysis
Biochem Biophys Res Commun. 2020 Aug 13;529(1):15-22.;doi: 10.1016/j.bbrc.2020.05.109.
149. Si-Yu Zeng,Qiu-Jiang Yan,Li Yang,Qing-Hua Mei,Hui-Qin Lu
Inhibition of the ROS-EGFR Pathway Mediates the Protective Action of Nox1/4 Inhibitor GKT137831 against Hypertensive Cardiac Hypertrophy via Suppressing Cardiac Inflammation and Activation of Akt and
Mediators Inflamm. 2020 Aug 4;2020:1078365.;doi: 10.1155/2020/1078365.
150. Tianlei Sun,Cheryl H T Kwong,Cheng Gao,Jianwen Wei,Ludan Yue,Jianxiang Zhang,Richard Dequan Ye,Ruibing Wang
Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine
Theranostics. 2020 Aug 8;10(22):10106-10119.;doi: 10.7150/thno.48448.
151. Zhicheng Zhang,Li Wang,Yawen Ding,Jinhui Wu,Yiqiao Hu,Ahu Yuan
Synergy of hypoxia relief and chromatin remodeling to overcome tumor radiation resistance
Biomater Sci. 2020 Sep 7;8(17):4739-4749.;doi: 10.1039/d0bm00119h.
152. Yi Zhao,Hong Liu,Xun Xi,Shuai Chen,Dongxu Liu
TRIM16 protects human periodontal ligament stem cells from oxidative stress-induced damage via activation of PICOT
Exp Cell Res. 2020 Dec 1;397(1):112336.;doi: 10.1016/j.yexcr.2020.112336.
153. Bingbing Zhang,Ming Li,Wei Yang,Juan J Loor,Yusheng Liang,Shuang Wang,Yingying Zhao,Han Guo,Xinru Ma,Liyun Yu,Chuang Xu
Mitochondrial dysfunction and endoplasmic reticulum stress in calf hepatocytes are associated with fatty acid-induced ORAI calcium release-activated calcium modulator 1 signaling
J Dairy Sci. 2020 Dec;103(12):11945-11956.;doi: 10.3168/jds.2020-18684.
154. Jie Wang,Nan Nan,Lulu Shi,Ning Li,Shuangzhan Huang,Ai Zhang,Yutong Liu,Peng Guo,Bao Liu,Zheng-Yi Xu
Arabidopsis BRCA1 represses RRTF1-mediated ROS production and ROS-responsive gene expression under dehydration stress
New Phytol. 2020 Dec;228(5):1591-1610.;doi: 10.1111/nph.16786.
155. Yan Yang,Jie Li,Lingqiang Zhang,Zeyuan Lin,Haiming Xiao,Xiaohong Sun,Meng Zhang,Peiqing Liu,Heqing Huang
CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes
Pharmacol Res. 2021 Jan;163:105333.;doi: 10.1016/j.phrs.2020.105333.