L-NMMA (总NOS抑制剂)
产品编号: S0011
产品包装:5mg
选择包装
5mg
数
量
L-NMMA (总NOS抑制剂)(S0011)
说明书下载
价格: ¥ 446.00
产品简介
使用说明
产品图片
相关产品
相关论文
产品问答
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| S0011 | L-NMMA (总NOS抑制剂) | 5mg | 446.00元 |
L-NMMA，即NG-Monomethyl-L-arginine,Monoacetate Salt，也称Nω-Me-L-Arg，或NG-Me-L-Arg, AcOH，是
NOS(nitric oxide synthase)广普性抑制剂。对于nNOS，IC50＝650nM；对于eNOS，IC50＝700nM；对于iNOS，IC50＝3.9μM。
L-NMMA分子量248.3，分子式为C7H16N4O2·C2H4O2，纯度大于99%。
本产品为L-NMMA的水溶液，浓度为50mg/ml (约200mM)，共100微升。
包装清单：
| 产品编号 | 产品名称 | 包装 |
| S0011 | L-NMMA(总NOS抑制剂) | 5mg |
| — | 说明书 | 1份 |
保存条件：
-20℃保存，半年有效。
注意事项：
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
使用说明：
L-NMMA的工作浓度通常为0.3-1mM。其最佳工作浓度需根据具体的实验，自行摸索。
L-NMMA的工作浓度通常为0.3-1mM。其最佳工作浓度需根据具体的实验，自行摸索。
相关产品请点击如下按钮：
一氧化氮相关
使用本产品的文献：
1. Zhong W, Zou G, Gu J, Zhang J.
L-arginine attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells.
Diabetes Res Clin Pract . 2010;89(1):38-45.
2. Tao L, Li X, Zhang L, Tian J, Li X, Sun X, Li X, Jiang L, Zhang X, Chen J.
Protective effect of tetrahydroxystilbene glucoside on 6-OHDA-induced apoptosis in PC12 cells through the ROS-NO pathway.
PLoS One . 2011;6(10):e26055. (IF 2.74)
3. Tang Y, Li T, Li J, Yang J, Liu H, Zhang XJ, Le W.
Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease.
Cell Death Differ . 2014 Mar;21(3):369-80. (IF 10.717)
4. Xiong J, Liu XH, Bui VB, Hong ZL, Wang LJ, Zhao Y, Fan H, Yang GX, Hu JF.
Phenolic constituents from the leaves of Cratoxylum formosum ssp. pruniflorum.
Fitoterapia . 2014 Apr;94:114-9. (IF 2.527)
5. Xiong J, Bui VB, Liu XH, Hong ZL, Yang GX, Hu JF.
Lignans from the stems of Clematis armandii (“Chuan-Mu-Tong”) and their anti-neuroinflammatory activities.
J Ethnopharmacol . 2014 May 14;153(3):737-43. (IF 3.69)
6. Yu L, Gao LX, Ma XQ, Hu FX, Li CM, Lu Z.
Involvement of superoxide and nitric oxide in BRAFV600E inhibitor PLX4032-induced growth inhibition of melanoma cells.
INTEGR BIOL-UK . 2014 Dec 18;6(12):1211-7. (IF 2.291)
7. She T, Qu L, Wang L, Yang X, Xu S, Feng J, Gao Y, Zhao C, Han Y, Cai S, Shou C.
Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Cancer Cell Growth by S Phase Arrest, Apoptosis, and Autophagy via Redox-Dependent ERK1/2 Pathway.
CANCER PREV RES . 2015 May;8(5):464-74. (IF 3.473)
8. Xiong J, Hong ZL, Xu P, Zou Y, Yu SB, Yang GX, Hu JF.
ent-Abietane diterpenoids with anti-neuroinflammatory activity from the rare Chloranthaceae plantChloranthus oldhamii.
Org Biomol Chem . 2016 May 18;14(20):4678-89. (IF 3.412)
9. Song JL, Yuan Y, Tan HB, Huang RM, Liu HX, Xu ZF, Qiu SX.
Anti-inflammatory and antimicrobial coumarins from the stems of Eurya chinensis.
J Asian Nat Prod Res . 2016 Jun 14:1-7. (IF 1.345)
10. Wang HF, Ning F, Liu ZC, Wu L, Li ZQ, Qi YF, Zhang G, Wang HS, Cai SH, Du J.
Histone deacetylase inhibitors deplete myeloid-derived suppressor cells induced by 4T1 mammary tumorsin vivo and in vitro.
CANCER IMMUNOL IMMUN . 2016 Dec 3.[Epub ahead of print] (IF 5.442)
11. Cao L, Li R, Chen X, Xue Y, Liu D.
Neougonin A Inhibits Lipopolysaccharide-Induced Inflammatory Responses via Downregulation of the NF-kB Signaling Pathway in RAW 264.7 Macrophages.
Inflammation . 2016 Dec;39(6):1939-1948. (IF 3.212)
12. Dong M, Liu D, Li YH, Chen XQ, Luo K, Zhang YM, Li RT.
Erratum: Naphthoquinones from Onosma paniculatum with Potential Anti-inflammatory Activity.
Planta Med . 2017 Jan 9. doi: 10.1055/s-0043-100122. [Epub ahead of print] (IF 2.687)
13. Wang HF, Ning F, Liu ZC, Wu L, Li ZQ, Qi YF, Zhang G, Wang HS, Cai SH, Du J.
Histone deacetylase inhibitors deplete myeloid-derived suppressor cells induced by 4T1mammary tumors in vivo and in vitro.
CANCER IMMUNOL IMMUN . 2017 Mar;66(3):355-66. (IF 5.442)
14. Chen XH, Liu SR, Peng B, Li D, Cheng ZX, Zhu JX, Zhang S, Peng YM, Li H, Zhang TT, Peng XX.
Exogenous l-Valine Promotes Phagocytosis to Kill Multidrug-Resistant Bacterial Pathogens.
Front Immunol . 2017 Mar 6;8:207. (IF 5.085)
15. Dong M, Liu D, Li YH, Chen XQ, Luo K, Zhang YM, Li RT.
Naphthoquinones from Onosma paniculatum with Potential Anti-inflammatory Activity.
Planta Med . 2017 May;83(7):631-5. (IF 2.687)
16. Wang TT, Shi ZQ, Hu LB, Xu XF, Han FX, Zhou LG, Chen J.
Thymol Ameliorates Cadmium-Induced Phytotoxicity inthe Root of Rice (Oryza sativa) Seedling by Decreasing Endogenous Nitric Oxide Generation.
J AGR FOOD CHEM . 2017 Aug 30;65(34):7396-405. (IF 4.192)
17. Jin P, Wiraja C, Zhao J, Zhang J, Zheng L, Xu C.
Nitric Oxide Nanosensors for Predicting the Development of Osteoarthritis in Rat Model.
ACS APPL MATER INTER . 2017 Aug 2;9(30):25128-37. (IF 8.758)
18. Dong G, Si C, Zhang Q, Yan F, Li C, Zhang H, Ma Q, Dai J, Li Z, Shi H, Wang B, Zhang J, Ming J, Hu Y, Geng S, Zhang Y, Li L, Xiong H.
Autophagy regulates accumulation and functional activity of granulocytic myeloid-derivedsuppressor cells via STAT3 signaling in endotoxin shock.
BBA-BIOMEMBRANES . 2017 Nov;1863(11):2796-807. (IF 3.411)
19. Zhan R, Wang F, Wu Y, Wang Y, Qian W, Liu M, Liu T, He W, Ren H, Luo G.
Nitric oxide promotes epidermal stem cell proliferation via FOXG1-c-Myc signalling.
NITRIC OXIDE-BIOL CH . 2018 Feb 28;73:1-8. (IF 3.311)
20. Lu Y, Lu D, Hu Y.
Glucagon-like peptide 2 decreases osteoclasts by stimulating apoptosis dependent on nitricoxide synthase.
CELL PROLIFERAT . 2018 Feb 19. doi: 10.1111/cpr.12443. (IF 5.753)
21. Lin Y,Tang G,Jiao Y,Yuan Y,Zheng Y,Chen Y,Xiao J,Li C,Chen Z,Cao P
Propionibacterium acnes Induces Intervertebral Disc Degeneration by Promoting iNOS/NO and COX-2/PGE2 Activation via the ROS-Dependent NF-κB Pathway.
Oxid Med Cell Longev . 2018 Aug 19;2018:3692752. (IF 5.076)
22. Luo J,Wei D,Li D,Wang L
Nitric oxide functions in stromal cell-derived factor-1-induced cytoskeleton changes and the migration of Jurkat cells.
Oncol Lett . 2018 Nov;16(5):6685-6690. (IF 2.311)
23. Yang P,Zhu W,Xu J,Liu W,Dong Z,Kikuchi T,Yamada T,Xie N,Feng F,Zhang J
Sesquiterpenoids and triterpenoids from Secamone lanceolata blume with inhibitory effects on nitric oxide production.
Fitoterapia. 2019 Mar;133:5-11. (IF 2.527)
24. Li M,Li B,Hou Y,Tian Y,Chen L,Liu S,Zhang N,Dong J
Anti-inflammatory effects of chemical components from Ginkgo biloba L. male flowers on lipopolysaccharide-stimulated RAW264.7 macrophages.
Phytother Res. 2019 Apr;33(4):989-997. (IF 4.087)
25. Zhang X,Li G,Guo Y,Song Y,Chen L,Ruan Q,Wang Y,Sun L,Hu Y,Zhou J,Ren B,Guo J
Regulation of ezrin tension by S-nitrosylation mediates non-small cell lung cancer invasion and metastasis.
Theranostics. 2019 Apr 13;9(9):2555-2571. (IF 8.579)
26. Li Q,Zhang Y,Jiang Q
SETD3 reduces KLC4 expression to improve the sensitization of cervical cancer cell to radiotherapy.
BIOCHEM BIOPH RES CO. 2019 Aug 27;516(3):619-625. (IF 2.985)
27. Zhao HW,Li JQ,Ding WJ
Chemical constituents from salt lake-derived Streptomyces sp. QHA10.
J Asian Nat Prod Res. 2019 Dec 17:1-7; (IF 1.345)
28. Wen-Xuan Li,Fei Wang,Yun-Qian Zhu,Li-Mei Zhang,Zhen-Hua Zhang,Xiao-Ming Wang
Inhibitors of nitric oxide synthase can reduce extracellular traps from neutrophils in asthmatic children in vitro
Pediatr Pulmonol. 2020 Jan;55(1):68-75.;doi: 10.1002/ppul.24520.
29. Hao-Wen Zhao,Jia-Qi Li,Wan-Jing Ding
Chemical constituents from salt lake-derived Streptomyces sp. QHA10
J Asian Nat Prod Res. 2021 Jan;23(1):26-32.;doi: 10.1080/10286020.2019.1700230.