moradec
链接：https://moradec.com
Moradec LLC由Helen（Hongyuan）Mao博士于2012年创立，主要目标是为快速经济的抗体–药物偶联物发现提供新的研究工具，加速抗体药物共轭物（ADC）的发现，这是一种针对癌症的靶向治疗。它们的二级抗体–药物共轭物（2°ADC）与各种细胞毒性药物如MMAE、MMAF、DM1或Duocarmycin连接，为快速、经济有效的方式预筛选针对癌细胞具有相关作用机制的靶抗体提供了可能。由一种与细胞毒性药物连接的抗体组成，已成为一种新的针对癌症的靶向治疗方法。
抗体偶联物（ADC）由抗体与细胞毒性药物连接而成，通过单克隆抗体部分选择性地结合到目标癌细胞。内化后，药物释放出来作用于癌细胞，实现了对肿瘤细胞的特异性杀伤，同时极大程度减少了细胞毒性药物对全身的毒性。
在细胞基础的毒性试验中使用2°ADC消除了直接将每个单克隆抗体与细胞毒性药物偶联的必要性，节省了与纯化和偶联相关的时间和成本。通过在2°ADC存在的情况下直接将裸抗体添加到细胞中，可以实现类似于单克隆抗体–药物共轭物中细胞内剂量依赖的药物释放效应，而不会影响表达目标受体水平较低的细胞。
Moradec的2°ADC表现出高度特异性，在没有主要抗体的情况下对细胞毒性极小，并且在未结合的二级抗体存在的情况下保持主要抗体的活性。这种方法简化了ADC的开发过程，增强了筛选和选择用于靶向癌症治疗的最佳抗体药物共轭物的效率。
Moradec的2°ADC具有高度特异性，在缺乏初级抗体的情况下对细胞的毒性最小。在存在未偶联的第二抗体的情况下，第一抗体活性没有明显变化。
Moradec的2°ADC使得能够快速筛选主要抗体引物，以确定最佳候选者用于特定ADC的开发。提供了一系列具有可切割或不可切割连接子的2°ADC，有助于测试针对特定细胞系的多种药物–连接子组合，以优化ADC格式。这些2°ADC也可应用于重组蛋白配体，用于靶向细胞表面受体。
部分产品信息
|
货号 |
产品名称 |
描述 |
规格 |
|
AH-101AF-50 |
αHFc-NC-MMAF |
IgGs Anti-Human IgG Fc-MMAF Antibody with Non-Cleavable Linker |
50µg |
|
AH-103D1-50 |
αHFc-NC-DM1 |
IgGs Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker |
50µg |
|
AH-201AF-50 |
Fab-αHFc-NC-MMAF |
Fab Anti-Human IgG Fc-MMAF Antibody with Non-Cleavable Linker |
50µg |
|
AH-121AF-50 |
αHFab-NC-MMAF |
IgGs Anti-Human IgG Fab-MMAF Antibody with Nonceavable Linker |
50µg |
|
AM-101AF-50 |
αMFc-NC-MMAF |
IgGs Anti-Mouse IgG Fc-MMAF Antibody with Non-Cleavable Linker |
50µg |
|
AO-101AF-50 |
αOFc-NC-MMAF |
IgGs Anti-Rabbit IgG Fc-MMAF Antibody with Non-Cleavable Linker |
50µg |
更多其它产品详情请查询Moradec网站或咨询Moradec中国代理上海金畔生物。
Moradec热卖产品
|
货号 |
产品名称 |
规格 |
品牌 |
|
AH-102AE-50 |
αHFc-CL-MMAE |
50μg |
Moradec |
|
AH-102AF-50 |
αHFc-CL-MMAF |
50μg |
Moradec |
|
AH-202AE-50 |
Fab-αHFc-CL-MMAE |
50μg |
Moradec |
|
AH-106PB-50 |
αHFc-CL-PBD |
50μg |
Moradec |
|
AH-101AF-50 |
αHFc-NC-MMAF |
50μg |
Moradec |
|
AH-107DX-50 |
αHFc-CL-DX8951 |
50μg |
Moradec |
|
AM-102AE-50 |
αMFc-CL-MMAE |
50μg |
Moradec |
|
AH-207DX-50 |
Fab-αHFc-CL-DX8951 |
50μg |
Moradec |
|
AM-102AF-50 |
IgGs Anti-Mouse IgG Fc-MMAF Antibody with Cleavable Linker |
50μg |
Moradec |
|
AH-202AF-50 |
Fab Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker 50µg |
50μg |
Moradec |
|
AH-122AE-50 |
IgGs Anti-Human IgG Fab-MMAE Antibody with Cleavable Linker 50µg |
50μg |
Moradec |
|
AM-107DX-50 |
αMFc-CL-DX8951 |
50μg |
Moradec |
|
AM-202AE-50 |
Fab-αMFc-CL-MMAE |
50μg |
Moradec |
|
AH-201AF-50 |
Fab-αHFc-NC-MMAF |
50μg |
Moradec |
|
AM-106PB-50 |
αHFc-CL-PBD |
50μg |
Moradec |
|
AH-102PN-50 |
αHFc-CL-PNU |
50μg |
Moradec |
|
AH-202AE-20 |
Fab-αHFc-CL-MMAE |
20μg |
Moradec |
|
AH-102AE-20 |
αHFc-CL-MMAE |
20μg |
Moradec |
|
AM-103D1-50 |
IgGs Anti-Mouse IgG Fc-DM1 Antibody with Non-Cleavable Linker 50µg |
50μg |
Moradec |
|
AM-202AE-20 |
Fab-αMFc-CL-MMAE |
20μg |
Moradec |
|
AM-101AF-50 |
IgGs Anti-Mouse IgG FC-MMAF Antibody with Non-CleavableLinker |
50μg |
Moradec |
|
AH-202DD-50 |
Fab Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker 50µg |
50μg |
Moradec |
|
AH-103D1-50 |
IgGs Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker 50µg |
50μg |
Moradec |
|
AM-201AF-50 |
Fab-αMFc-NC-MMAF |
50μg |
Moradec |
|
AH-203D1-20 |
Fab Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker 20µg |
20μg |
Moradec |
|
AM-203D1-20 |
Fab Anti-Mouse IgG Fc-DM1 Antibody with Noncleavable Linker 20µg |
20μg |
Moradec |
|
AM-107DX-20 |
IgGs Anti-Mouse IgG Fc-DX8951 Antibody with Cleavable Linker 20µg |
20μg |
Moradec |
|
AM-203D1-50 |
Fab-αMFc-NC-DM1 |
50μg |
Moradec |
|
AO-112AE-20 |
IgGs Anti-Rabbit IgG(H+L)-MMAE Antibody with Cleavable Linker 20µg |
20μg |
Moradec |
|
AO-112AE-50 |
IgGs Anti-Rabbit IgG(H+L)-MMAE Antibody with Cleavable Linker 50µg |
50μg |
Moradec |
|
AM-103D1-20 |
IgGs Anti-Mouse IgG Fc-DM1 Antibody with Non-Cleavable Linker 20µg |
20μg |
Moradec |
|
AM-102AE-20 |
αMFc-CL-MMAE |
20μg |
Moradec |
|
AM-102-AE-50 |
αMFc-CL-MMAE |
50μg |
Moradec |
|
AH-207DX-20 |
Fab Anti-human IgG Fc-DX8951 Antibody with Cleavable Linker 20µg |
20μg |
Moradec |
|
AH-202-AE |
Fab-αHFc-CL-MMAE |
ea |
Moradec |
|
AH-122AF-50 |
IgGs Anti-Human IgG Fab-MMAF Antibody with Cleavable Linker 50µg |
50μg |
Moradec |
|
AH-102-AE |
αHFc-CL-MMAE |
ea |
Moradec |
|
AH-123D1-50 |
IgGs Anti-Human IgG Fab-DM1 Antibody with Non-Cleavable Linker 50µg |
50μg |
Moradec |
|
AH-121AF-50 |
IgGs Anti-Human IgG Fab-MMAF Antibody with Nonceavable Linker 50µg |
50μg |
Moradec |
|
AH-102AF-20 |
IgGs Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker 20µg |
20μg |
Moradec |
|
AH-102AE-50 |
αHFc-CL-MMAE |
50μg |
Moradec |
|
AH-102AF-50 |
αHFc-CL-MMAF |
50μg |
Moradec |
|
AH-202AE-50 |
Fab-αHFc-CL-MMAE |
50μg |
Moradec |
|
AH-106PB-50 |
αHFc-CL-PBD |
50μg |
Moradec |
|
AH-101AF-50 |
αHFc-NC-MMAF |
50μg |
Moradec |
|
AH-107DX-50 |
αHFc-CL-DX8951 |
50μg |
Moradec |
|
AM-102AE-50 |
αMFc-CL-MMAE |
50μg |
Moradec |
|
AH-207DX-50 |
Fab-αHFc-CL-DX8951 |
50μg |
Moradec |
|
AM-102AF-50 |
IgGs Anti-Mouse IgG Fc-MMAF Antibody with Cleavable Linker |
50μg |
Moradec |
|
AH-202AF-50 |
Fab Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker 50µg |
50μg |
Moradec |