DiO (细胞膜绿色荧光探针)(C1038)

DiO (细胞膜绿色荧光探针)

产品编号: C1038

产品包装:10mg
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10mg

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456.00 10

价格: ¥ 456.00

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C1038 DiO (细胞膜绿色荧光探针) 10mg 456.00元

DiO即DiOC18(3),全称为3,3′-dioctadecyloxacarbocyanine perchlorate,是最常用的细胞膜荧光探针之一,呈现绿色荧光。DiO是一种亲脂性膜染料,进入细胞膜后可以侧向扩散逐渐使整个细胞的细胞膜被染色。
DiO在进入细胞膜之前荧光非常弱,仅当进入到细胞膜后才可以被激发出很强的荧光。DiO被激发后可以发出绿色的荧光,DiO和磷酯双层膜结合后的激发光谱和发射光谱参考下图。其中,最大激发波长为484nm,最大发射波长为501nm。

DiO (细胞膜绿色荧光探针)(C1038) DiO (细胞膜绿色荧光探针)(C1038)

DiO的分子式为C53H85ClN2O6,分子量为881.72,CAS number为34215-57-1。
DiO可以溶解于无水乙醇、DMSO和DMF,其中在DMSO中溶解度大于10mg/ml。发现较难溶解时可以适当加热,并用超声处理以促进溶解。
DiO被广泛用于正向或逆向的,活的或固定的神经等细胞或组织的示踪剂或长期示踪剂(long-term tracer)。DiO通常不会明显影响细胞的生存力(viability)。DiO对于细胞膜染色的荧光强度通常要低于DiI,有时对于某些经过固定的组织的染色效果欠佳。
DiO除了最简单的细胞膜荧光标记外,还可以用于检测细胞的融合和粘附,检测发育或移植过程中细胞迁移,通过FRAP(Fluorescence Recovery After Photobleaching)检测脂在细胞膜上的扩散,检测细胞毒性和标记脂蛋白等。
用于细胞膜荧光标记时,DiO的常用浓度为1-30μM,最常用的浓度为5-10μM。DiO可以直接染色活的细胞或组织,染色时间通常为5-20分钟。对于固定的细胞或组织,通常宜使用配制在PBS中的4%多聚甲醛进行固定,使用其它不适当的固定液会导致荧光背景较高。
包装清单:

产品编号 产品名称 包装
C1038 DiO (细胞膜绿色荧光探针) 10mg
说明书 1份

保存条件:
4℃避光保存,一年有效。配制的储存液-20℃避光保存,半年有效。
注意事项:
荧光染料均存在淬灭问题,请尽量注意避光,以减缓荧光淬灭。
本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
为了您的安全和健康,请穿实验服并戴一次性手套操作。 

DiO (细胞膜绿色荧光探针)(C1038)

相关产品请点击如下按钮:
荧光染色
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79. Cai X,Yang Q,Weng Q,Wang S
pH sensitive doxorubicin-loaded nanoparticle based on Radix pseudostellariae protein-polysaccharide conjugate and its improvement on HepG2 cellular uptake of doxorubicin.
Food Chem Toxicol. 2020 Feb;136:111099. (IF 4.679)

80. Lin M,Guo W,Zhang Z,Zhou Y,Chen J,Wang T,Zhong X,Lu Y,Yang Q,Wei Q,Han M,Xu D,Gao J
Reduced Toxicity of Liposomal Nitrogen Mustard Prodrug Formulation Activated by an Intracellular ROS Feedback Mechanism in Hematological Neoplasm Models.
MOL PHARMACOL. 2020 Feb 3;17(2):499-506. (IF 3.664)

81. Peitao Zhou,Qianqin Li,Shuwen Su,Wenhui Dong,Suyu Zong,Qiong Ma,Xi Yang,Daming Zuo,Shaoyi Zheng,Xianzhong Meng,Dingli Xu,Qingchun Zeng
Interleukin 37 Suppresses M1 Macrophage Polarization Through Inhibition of the Notch1 and Nuclear Factor Kappa B Pathways
Front Cell Dev Biol. 2020 Feb 14;8:56.;doi: 10.3389/fcell.2020.00056. (IF 5.201)

82. Feng Liu,Junlin Sun,Wenqian Yu,Qunying Jiang,Min Pan,Zhen Xu,Fengye Mo,Xiaoqing Liu
Quantum dot-pulsed dendritic cell vaccines plus macrophage polarization for amplified cancer immunotherapy
Biomaterials. 2020 Feb 29;242:119928.;doi: 10.1016/j.biomaterials.2020.119928. (IF 10.317)

83. Xixi Cai,Qian Yang,Qingxia Weng,Shaoyun Wang
pH sensitive doxorubicin-loaded nanoparticle based on Radix pseudostellariae protein-polysaccharide conjugate and its improvement on HepG2 cellular uptake of doxorubicin
Food Chem Toxicol. 2020 Feb;136:111099.;doi: 10.1016/j.fct.2019.111099. (IF 4.679)

84. Di Wang,Changfu Hao,Lin Zhang,Jianhui Zhang,Suna Liu,Yiping Li,Yaqian Qu,Youliang Zhao,Ruoxuan Huang,Jingjing Wei,Wu Yao
Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdifferentiation
ECOTOX ENVIRON SAFE. 2020 Apr 1;192:110253.;doi: 10.1016/j.ecoenv.2020.110253. (IF 4.872)

85. Yi Liu,Jingtong Zhao,Jinlan Jiang,Fangfang Chen,Xuedong Fang
Doxorubicin Delivered Using Nanoparticles Camouflaged with Mesenchymal Stem Cell Membranes to Treat Colon Cancer
INT J NANOMED. 2020 Apr 23;15:2873-2884.;doi: 10.2147/IJN.S242787. (IF 5.115)

86. Xin Chang,Lei Xing,Yi Wang,Tian-Jiao Zhou,Li-Jun Shen,Hu-Lin Jiang
Nanoengineered immunosuppressive therapeutics modulating M1/M2 macrophages into the balanced status for enhanced idiopathic pulmonary fibrosis therapy
Nanoscale. 2020 Apr 30;12(16):8664-8678.;doi: 10.1039/d0nr00750a. (IF 6.895)

87. Gen-Que Fu,Sheng-Chun Zhang,Ge-Gu Chen,Xiang Hao,Jing Bian,Feng Peng
Xylan-based hydrogels for potential skin care application
Int J Biol Macromol. 2020 Apr 30;158:244-250.;doi: 10.1016/j.ijbiomac.2020.04.235. (IF 5.162)

88. Xianmou Fan,Shaobing Wang,Yan Fang,Peiyuan Li,Weikang Zhou,Zhengchao Wang,Mingfeng Chen,Haiqing Liu
Tough polyacrylamide-tannic acid-kaolin adhesive hydrogels for quick hemostatic application
MAT SCI ENG C-MATER. 2020 Apr;109:110649.;doi: 10.1016/j.msec.2020.110649. (IF 5.88)

89. Zhiping Yu,Ming Hu,Zhouquan Li,Dan Xu,Lianhua Zhu,Yanli Guo,Qiuli Liu,Weihua Lan,Jun Jiang,Luofu Wang
Anti-G250 nanobody-functionalized nanobubbles targeting renal cell carcinoma cells for ultrasound molecular imaging
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90. Xiaohong Yang,Timon Chengyi Liu,Shaojie Liu,Weicong Zhu,Honglin Li,Peihong Liang,Suihui Ye,Shuliang Cui
Promoted Viability and Differentiated Phenotype of Cultured Chondrocytes With Low Level Laser Irradiation Potentiate Efficacious Cells for Therapeutics
Front Bioeng Biotechnol. 2020 May 29;8:468.;doi: 10.3389/fbioe.2020.00468.

91. Hai Qiao,Zixin Wei,Yiting Wang,Na Hu,Sineng Sun,Jin Bai,Liaoqiong Fang,Zhibiao Wang
Focused characteristics and effects of light reflected from spherical lipid membrane of giant unilamellar vesicles
COLLOID SURFACE B. 2020 May;189:110828.;doi: 10.1016/j.colsurfb.2020.110828. (IF 4.389)

92. Yuchen Dai,Yi Yang,Baohong Liu,Liang Qiao
Water-in-oil microcompartments for the study of biomimetic drug metabolism
J COLLOID INTERF SCI. 2020 Jun 1;569:378-385.;doi: 10.1016/j.jcis.2020.02.096. (IF 7.489)

93. Hao Shen,Emile Nibona,Gongyu Xu,Md Abdullah Al Hafiz,Xiaomei Ke,Xiaoting Liang,Qiting Yao,Xueping Zhong,Qingchun Zhou,Haobin Zhao
Identification, expression pattern, and immune response of Tim-1 and Tim-4 in embryos and adult medaka (Oryzias latipes)
J Exp Zool B Mol Dev Evol. 2020 Jun;334(4):235-244.;doi: 10.1002/jez.b.22939. (IF 1.14)

94. Honglian Li,Ruirui Lu,Yu Pang,Jicheng Li,Yiwen Cao,Hongxin Fu,Guoxing Fang,Qiuhe Chen,Bihao Liu,Junbiao Wu,Yuan Zhou,Jiuyao Zhou
Zhen-Wu-Tang Protects IgA Nephropathy in Rats by Regulating Exosomes to Inhibit NF-κB/NLRP3 Pathway
Front Pharmacol. 2020 Jul 16;11:1080.;doi: 10.3389/fphar.2020.01080. (IF 4.225)

95. Jinheng Wang,Guangmeng Li,Chenggong Tu,Xiaoming Chen,Bin Yang,Yongliang Huo,Yi Li,Ai-Zheng Chen,Ping Lan,Yu Shrike Zhang,Maobin Xie
High-throughput single-cell analysis of exosome mediated dual drug delivery, in vivo fate and synergistic tumor therapy
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96. Feifei Li,Lei Zhan,Qian Dong,Qiwei Wang,Yuanhe Wang,Xiaoyan Li,Yong Zhang,Jingdong Zhang
Tumor-Derived Exosome-Educated Hepatic Stellate Cells Regulate Lactate Metabolism of Hypoxic Colorectal Tumor Cells via the IL-6/STAT3 Pathway to Confer Drug Resistance
ONCOTARGETS THER. 2020 Aug 7;13:7851-7864.;doi: 10.2147/OTT.S253485. (IF 3.337)

97. Yuan Liang,Hengli Yang,Qiaoying Li,Ping Zhao,Han Li,Yuxin Zhang,Wenbin Cai,Xiaoju Ma,Yunyou Duan
Novel biomimetic dual-mode nanodroplets as ultrasound contrast agents with potential ability of precise detection and photothermal ablation of tumors
CANCER CHEMOTH PHARM. 2020 Sep;86(3):405-418.;doi: 10.1007/s00280-020-04124-x. (IF 2.967)

98. Zhen Wang,Chenghui Yang,Lili Li,Zhigang Zhang,Jun Pan,Ke Su,Wuzhen Chen,Jinfan Li,Fuming Qiu,Jian Huang
CD62L dim Neutrophils Specifically Migrate to the Lung and Participate in the Formation of the Pre-Metastatic Niche of Breast Cancer
Front Oncol. 2020 Oct 15;10:540484.;doi: 10.3389/fonc.2020.540484. (IF 4.848)

99. Xingyu Zhang,Jun Chen,Qin Jiang,Xiaoquan Ding,Yunxia Li,Chen Chen,Wuli Yang,Shiyi Chen
Highly biosafe biomimetic stem cell membrane-disguised nanovehicles for cartilage regeneration
J Mater Chem B. 2020 Oct 7;8(38):8884-8893.;doi: 10.1039/d0tb01686a. (IF 5.344)

100. Ning Zhang,Yanan Song,Zheyong Huang,Jing Chen,Haipeng Tan,Hongbo Yang,Mengkang Fan,Qiyu Li,Qiaozi Wang,Jinfeng Gao,Zhiqing Pang,Juying Qian,Junbo Ge
Monocyte mimics improve mesenchymal stem cell-derived extracellular vesicle homing in a mouse MI/RI model
Biomaterials. 2020 Oct;255:120168.;doi: 10.1016/j.biomaterials.2020.120168. (IF 10.317)

101. Pengwei Luan,Xinyue Ding,Jiazhen Xu,Lixian Jiang,Yulan Xu,Yuying Zhu,Ruixiang Li,Jiange Zhang
Salvianolate reduces neuronal apoptosis by suppressing OGD-induced microglial activation
Life Sci. 2020 Nov 1;260:118393.;doi: 10.1016/j.lfs.2020.118393. (IF 3.647)

102. Xiaofen Xie,Xinying Li,Jinfeng Lei,Xi Zhao,Yongbo Lyu,Changdao Mu,Defu Li,Liming Ge,Yongbin Xu
Oxidized starch cross-linked porous collagen-based hydrogel for spontaneous agglomeration growth of adipose-derived stem cells
MAT SCI ENG C-MATER. 2020 Nov;116:111165.;doi: 10.1016/j.msec.2020.111165. (IF 5.88)

103. Yubing Han,Zhimin Zhang,Wenjie Liu,Yuanfa Yao,Yingke Xu,Xu Liu,Cuifang Kuang,Xiang Hao
A Labeling Strategy for Living Specimens in Long-Term/Super-Resolution Fluorescence Imaging
Front Chem. 2021 Jan 15;8:601436.;doi: 10.3389/fchem.2020.601436. (IF 3.693)

104. Chang-Chun Chen,Jing Chen,Wen-Liang Wang,Liang Xie,Chuan-Qiang Shao,Yan-Xiang Zhang
Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell-Derived Exosomes on the Senescence of Nucleus Pulposus Cells
Orthop Surg. 2021 Apr;13(2):583-591.;doi: 10.1111/os.12886. (IF 1.718)

105. Guangshu Wang,Zhenyu Wang,Ning Sun,Yurong Cai,Xiaogang Yang
Reactive oxygen species-responsive silk sericin microcapsules used for antioxidative stress damage
Microsc Res Tech. 2021 Apr;84(4):618-626.;doi: 10.1002/jemt.23620.