Lyso-Tracker Red (溶酶体红色荧光探针)(C1046)

Lyso-Tracker Red (溶酶体红色荧光探针)

产品编号: C1046

产品包装:50μl
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50μl

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368.00 10

价格: ¥ 368.00

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产品编号 产品名称 产品包装 产品价格
C1046 Lyso-Tracker Red (溶酶体红色荧光探针) 50μl 368.00元

Lyso-Tracker Red是一种溶酶体(lysosome)红色荧光探针,能通透细胞膜,可以用于活细胞溶酶体特异性荧光染色。
Lyso-Tracker Red为采用Molecular Probes公司的DND-99进行了荧光标记的带有弱碱性的荧光探针,其中仅弱碱可部分提供质子,以维持pH在中性,可以选择性地滞留在偏酸性的溶酶体中,从而实现对于溶酶体的特异性荧光标记。中性红(Neutral Red)和吖啶橙(Acridine Orange)也都可以对溶酶体进行荧光染色,但中性红和吖啶橙的染色缺乏特异性。Lyso-Tracker Red适用于活细胞溶酶体的荧光染色,但不适合用于固定细胞溶酶体的荧光染色。Lyso-Tracker Red分子的化学结构式参考图1。
Lyso-Tracker Red (溶酶体红色荧光探针)(C1046) 图1.Lyso-Tracker Red的化学结构式。 Lyso-Tracker Red的分子式为C20H24BF2N5O,分子量为399.25,最大激发波长为577nm,最大发射波长为590nm。Lyso-Tracker Red的激发光谱和发射光谱参考图2。
Lyso-Tracker Red (溶酶体红色荧光探针)(C1046) 图2.Lyso-Tracker Red的激发光谱和发射光谱。 Lyso-Tracker Red是嗜酸性荧光探针,用于活细胞内酸性细胞器的标记和示踪。这些探针具有几个重要特征,包括高度选择靶向酸性细胞器和在纳摩尔浓度有效标记活细胞。Lyso-Tracker Red必须在极低浓度(通常约50nM)下才能获得优异的选择性。这些探针的滞留(retention)机制虽然没有被研究清楚,但很可能与酸性细胞器的质子化和滞留性有关,Lyso-Tracker Red探针的内吞作用动力学研究显示染料进入活细胞的摄入时间仅几秒即可。然而,这些溶酶体探针会导致溶酶体被碱化,长期孵育会诱使溶酶体pH值的增加。因此,建议成像前用探针孵育细胞的时间不能太久。Lyso-Tracker Red探针具体使用浓度和孵育时间需要根据自身实验条件和具体细胞种类来进行摸索以达到满意的染色效果。Lyso-Tracker Red在活细胞中染色效果参考图3。
Lyso-Tracker Red (溶酶体红色荧光探针)(C1046) 图3.Lyso-Tracker Red对于NRK-52E(大鼠肾小管上皮细胞)的染色效果。Mito-Tracker Green (C1048)染色的NRK-52E细胞其线粒体呈现绿色荧光(图B),Lyso-Tracker Red (C1046)染色的NRK-52E细胞其溶酶体呈现红色荧光(图C),绿色荧光、红色荧光及细胞核蓝色荧光的叠加(merge)效果见图D。其中细胞核使用Hoechst 33342 (C1027)染色。实际检测效果会因实验条件、检测仪器等的不同而存在差异,图中数据仅供参考。
Lyso-Tracker Red适用于活细胞溶酶体的荧光染色,但不适合用于固定细胞溶酶体的荧光染色。如果经Lyso-Tracker Red染色后的细胞需要进行固定操作,可以尝试3%的戊二醛(glutaraldehyde)。
按照1:20000的比例稀释,可以配制1000ml Lyso-Tracker Red工作液。
包装清单:

产品编号 产品名称 包装
C1046 Lyso-Tracker Red (1mM) 50µl
说明书 1份

保存条件:
-20℃避光保存,半年有效。
注意事项:
Lyso-Tracker Red (1mM)在4℃、冰浴等较低温度情况下会凝固而粘在离心管管底、管壁或管盖内,可以20-25℃水浴温育片刻至全部融解后使用。对于微量的液体,每次使用前先离心数秒钟,使液体充分沉降到管底。
荧光染料均存在淬灭问题,请尽量注意避光,以减缓荧光淬灭。
Lyso-Tracker Red适用于活细胞溶酶体荧光染色,但不适合用于固定细胞溶酶体的荧光染色。如果经Lyso-Tracker Red染色后的细胞需要进行固定操作,可以尝试3%的戊二醛(glutaraldehyde)。
需自备盖玻片和载玻片(可以向碧云天订购)。
本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
为了您的安全和健康,请穿实验服并戴一次性手套操作。

使用说明:
1.Lyso-Tracker Red工作液的配制:
a.取少量Lyso-Tracker Red按照1:13333-1:20000的比例加入到细胞培养液或适当的溶液(例如含钙镁离子的HBSS)中,使最终浓度为50-75nM。例如取1µl Lyso-Tracker Red加入到20ml或13.33ml细胞培养液或适当的溶液(例如含钙镁离子的HBSS)中。混匀后即为Lyso-Tracker Red工作液。HBSS with Ca2+ & Mg2+ (C0219)可以向碧云天订购。
b.Lyso-Tracker Red工作液使用前需37℃预温育。
注:工作液中Lyso-Tracker Red的浓度可以根据实际情况进行适当调整。为降低背景,在染色效果可以接受的范围内,建议尽量使用较低浓度的Lyso-Tracker Red。
2.溶酶体的荧光标记:
a.去除细胞培养液,加入步骤1配制好的并37℃预温育的Lyso-Tracker Red染色工作液,与细胞37℃共孵育5-60分钟。
b.去除Lyso-Tracker Red染色工作液,加入新鲜的细胞培养液。
c.随后通常用荧光显微镜或激光共聚焦显微镜进行观察。此时可观察到溶酶体呈明亮的强荧光染色。如果染色效果欠佳,可以提高Lyso-Tracker Red染色工作液中Lyso-Tracker Red的浓度或在推荐的时间范围内适当延长染色时间。

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Lyso-Tracker Red (溶酶体红色荧光探针)(C1046)

相关产品请点击如下按钮:
荧光染色
细胞器荧光探针

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57. Zhang L,Qin Y,Zhang Z,Fan F,Huang C,Lu L,Wang H,Jin X,Zhao H,Kong D,Wang C,Sun H,Leng X,Zhu D
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Acta Biomater . 2018 Jul 15;75:371-385. (IF 7.242)

58. Liu H,Wang J,Li W,Hu J,Wang M,Kang Y
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Pharmaceutics . 2018 Jul 19;10(3). pii: E99. (IF 4.421)

59. E S,Mao QX,Yuan XL,Kong XL,Chen XW,Wang JH
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Nanoscale . 2018 Jul 9;10(26):12788-12796. (IF 6.895)

60. Chen F,Song Q,Yu Q
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Am J Cancer Res. 2018 Aug 1;8(8):1466-1482. eCollection 2018. (IF 5.177)

61. Song ZT,Zhang LW,Fan LQ,Kong JW,Mao JH,Zhao J,Wang FJ
Enhanced anticancer effect of MAP30-S3 by cyclosproin A through endosomal escape.
ANTI-CANCER DRUG . 2018 Sep;29(8):736-747. (IF 2.26)

62. Gong X,Sun R,Gao Z,Han W,Liu Y,Zhao L,Jing L,Yao X,Sun X
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Front Pharmacol . 2018 Sep 26;9:1044. (IF 4.225)

63. Liu Z,Mei T
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Mol Med Rep . 2018 Oct;18(4):4016-4022. (IF 2.1)

64. Yang Y,Gao J,Zhang Y,Xu W,Hao Y,Xu Z,Tao L
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Environ Pollut . 2018 Oct;241:1091-1097. (IF 6.792)

65. Chang M,Song X,Geng X,Wang X,Wang W,Chen TC,Xie L,Song X
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J EXP CLIN CANC RES . 2018 Oct 16;37(1):250. (IF 7.068)

66. Li MZ,Zheng LJ,Shen J,Li XY,Zhang Q,Bai X,Wang QS,Ji JG
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Neural Regen Res . 2018 Nov;13(11):2005-2013. (IF 3.171)

67. Jiang L,Liang X,Liu G,Zhou Y,Ye X,Chen X,Miao Q,Gao L,Zhang X,Mei L
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Drug Deliv . 2018 Nov;25(1):985-994. (IF 4.902)

68. Qin C,Lv Y,Xu C,Li J,Yin L,He W
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INT J PHARMACOL . 2018 Nov 15;551(1-2):8-13. (IF 0.692)

69. Li J,Han Y,Lu Y,Song B,Zhao M,Hu H,Chen D
A novel disulfide bond-mediated cleavable RGD-modified PAMAM nanocomplex containing nuclear localization signal HMGB1 for enhancing gene transfection efficiency.
INT J NANOMED . 2018 Nov 6;13:7135-7153. (IF 5.115)

70. Zhao Q,Zhao H,Guo Y,Zhang Z,Hu Y,Tang Y
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Anal Chem . 2018 Nov 6;90(21):12663-12669. (IF 6.785)

71. Liu B,Cao W,Li J,Liu J
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Cell Calcium . 2018 Dec;76:62-71. (IF 4.874)

72. Lv Z,Qiu L,Liu Z,Wang W,Chen H,Jia Y,Jia Z,Jiang S,Wang L,Song L
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Dev Comp Immunol . 2018 Dec;89:152-162. (IF 3.192)

73. Mai CT,Wu MM,Wang CL,Su ZR,Cheng YY,Zhang XJ
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Mol Immunol. 2019 Jan;105:76-85. (IF 3.641)

74. Lei P,Tian S,Teng C,Huang L,Liu X,Wang J,Zhang Y,Li B,Shan Y
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Mol Nutr Food Res . 2019 Feb;63(4):e1800795. (IF 5.309)

75. Zheng Y,Tu C,Zhang J,Wang J
Inhibition of multiple myeloma‑derived exosomes uptake suppresses the functional response in bone marrow stromal cell.
Int J Oncol. 2019 Mar;54(3):1061-1070. (IF 3.899)

76. Du X,Zhang T,Ma G,Gu X,Wang G,Li J
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INT J NANOMED. 2019 Apr 2;14:2233-2251. (IF 5.115)

77. Qiu JF,Li X,Cui WZ,Liu XF,Tao H,Yang K,Dai TM,Sima YH,Xu SQ
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Front Physiol. 2019 May 3;10:537. (IF 3.367)

78. Chen H,Li L,Hu J,Zhao Z,Ji L,Cheng C,Zhang G,Zhang T,Li Y,Chen H,Pan S,Sun B
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J EXP CLIN CANC RES. 2019 Jul 9;38(1):297. (IF 7.068)

79. Wu H, Zhuang Q, Xu J, Xu L, Zhao Y, Wang C, Yang Z, Shen F, Liu Z, Peng R.
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BIOCONJUGATE CHEM. 2019 Aug 21;30(8):2115-2126. (IF 4.031)

80. Ren Y,Li Y,Lv J,Guo X,Zhang J,Zhou D,Zhang Z,Xue Z,Yang G,Xi Q,Liu H,Liu Z,Zhang L,Zhang Q,Yao Z,Zhang R,Da Y
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J Cell Biochem. 2019 Sep;120(9):15695-15708. (IF 4.237)

81. Liu Z,Ren F,Zhang H,Yuan Q,Jiang Z,Liu H,Sun Q,Li Z
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82. He C,Zhang X,Yan R,Zhao P,Chen Y,Li M,Chen C,Fan T,Lu Y,Wang C,Wu F,Lee RJ,Yang T,Xiang G
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BIOMATER SCI-UK. 2019 Oct 1;7(10):4260-4272. (IF 6.183)

83. Liu Y,Zhong Y,Tian W,Lan F,Kang J,Pang H,Hou H,Li D
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84. Lei M,Ma G,Sha S,Wang X,Feng H,Zhu Y,Du X
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Drug Deliv. 2019 Dec;26(1):262-272. (IF 4.902)

85. Li T,Chen Q,Zheng Y,Zhang P,Chen X,Lu J,Lv Y,Sun S,Zeng W
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86. Kai Niu,Chunjie Guo,Shiyong Teng,Dandan Zhou,Shuyuan Yu,Wanzhong Yin,Ping Wang,Wei Zhu,Maoli Duan
Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation
PLoS One. 2020 Jan 15;15(1):e0227408.;doi: 10.1371/journal.pone.0227408. (IF 2.74)

87. Xiu He,Shi Chen,Chao Li,Jiaqi Ban,Yungeng Wei,Yangyang He,Fangwei Liu,Ying Chen,Jie Chen
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages
Cells. 2020 Jan 4;9(1):122.;doi: 10.3390/cells9010122. (IF 4.366)

88. Ling-Hong Huang,Jin Han,Jian-Ming Ouyang,Bao-Song Gui
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89. Yingying Zhang,Yanliang Zhao,Yingnan Wu,Bing Zhao,Liyan Wang,Bo Song
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SPECTROCHIM ACTA A. 2020 Feb 15;227:117767.;doi: 10.1016/j.saa.2019.117767. (IF 3.232)

90. Xiaoteng Fan,Tingting Hou,Shuai Zhang,Yongjing Guan,Jia Jia,Zaizhao Wang
The cellular responses of autophagy, apoptosis, and 5-methylcytosine level in zebrafish cells upon nutrient deprivation stress
Chemosphere. 2020 Feb;241:124989.;doi: 10.1016/j.chemosphere.2019.124989. (IF 5.778)

91. Lei Wang,Xiuxiu Niu,Qingling Song,Jiajia Jia,Yongwei Hao,Cuixia Zheng,Kaili Ding,Huifang Xiao,Xinxin Liu,Zhenzhong Zhang,Yun Zhang
A two-step precise targeting nanoplatform for tumor therapy via the alkyl radicals activated by the microenvironment of organelles
J Control Release. 2020 Feb;318:197-209.;doi: 10.1016/j.jconrel.2019.10.017. (IF 7.727)

92. Xia Yuan,Wen Nie,Zhiyao He,Jingyun Yang,Bin Shao,Xuelei Ma,Xiangxian Zhang,Zhenfei Bi,Lu Sun,Xiao Liang,Yan Tie,Yu Liu,Fei Mo,Dan Xie,Yuquan Wei,Xiawei Wei
Carbon black nanoparticles induce cell necrosis through lysosomal membrane permeabilization and cause subsequent inflammatory response
Theranostics. 2020 Mar 15;10(10):4589-4605.;doi: 10.7150/thno.34065. (IF 8.579)

93. Hui Zou,Tao Wang,Junzhao Yuan,Jian Sun,Yan Yuan,Jianhong Gu,Xuezhong Liu,Jianchun Bian,Zongping Liu
Cadmium-induced cytotoxicity in mouse liver cells is associated with the disruption of autophagic flux via inhibiting the fusion of autophagosomes and lysosomes
Toxicol Lett. 2020 Mar 15;321:32-43.;doi: 10.1016/j.toxlet.2019.12.019. (IF 3.569)

94. Ziyi Wang,Xiao Chu,Na Li,Lingling Fu,Hongzhou Gu,Nan Zhang
Engineered DNA nanodrugs alleviate inflammation in inflammatory arthritis
INT J PHARMACOL. 2020 Mar 15;577:119047.;doi: 10.1016/j.ijpharm.2020.119047. (IF 0.692)

95. Jia Lv,Echuan Tan,Yuqing Wang,Qianqian Fan,Jingwen Yu,Yiyun Cheng
Tailoring guanidyl-rich polymers for efficient cytosolic protein delivery
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96. Lei Fang,Hua Lin,Zhenfeng Wu,Zhen Wang,Xinxin Fan,Ziting Cheng,Xiaoya Hou,Daquan Chen
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CARBOHYD POLYM. 2020 Apr 15;234:115930.;doi: 10.1016/j.carbpol.2020.115930. (IF 7.182)

97. Liang Jin,Chenxin Chen,Gaozhi Jia,Yutong Li,Jian Zhang,Hua Huang,Bin Kang,Guangyin Yuan,Hui Zeng,Tongxin Chen
The bioeffects of degradable products derived from a biodegradable Mg-based alloy in macrophages via heterophagy
Acta Biomater. 2020 Apr 1;106:428-438.;doi: 10.1016/j.actbio.2020.02.002. (IF 7.242)

98. Chen Li,Xue-Wei Cao,Jian Zhao,Fu-Jun Wang
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99. Dong Xu,Yuxin Wan,Zhihao Li,Chunbao Wang,Qingxia Zou,Chang Du,Yingjun Wang
Tailorable hierarchical structures of biomimetic hydroxyapatite micro/nano particles promoting endocytosis and osteogenic differentiation of stem cells
BIOMATER SCI-UK. 2020 Jun 21;8(12):3286-3300.;doi: 10.1039/d0bm00443j. (IF 6.183)

100. Yi Qi,Ru Ma,Xueyan Li,Songqing Lv,Xiaoying Liu,Alimire Abulikemu,Xinying Zhao,Yanbo Li,Caixia Guo,Zhiwei Sun
Disturbed mitochondrial quality control involved in hepatocytotoxicity induced by silica nanoparticles
Nanoscale. 2020 Jun 25;12(24):13034-13045.;doi: 10.1039/d0nr01893g. (IF 6.895)

101. Lu Tan,Tao Zheng,Man Li,Xiaofang Zhong,Yao Tang,Ming Qin,Xun Sun
Optimization of an mRNA vaccine assisted with cyclodextrin-polyethyleneimine conjugates
DRUG DELIV TRANSL RE. 2020 Jun;10(3):678-689.;doi: 10.1007/s13346-020-00725-4. (IF 2.664)

102. Na Chen,Xiaofeng Tang,Zhaoyang Ye,Shanshan Wang,Xianjin Xiao
Methylmercury disrupts autophagic flux by inhibiting autophagosome-lysosome fusion in mouse germ cells
ECOTOX ENVIRON SAFE. 2020 Jul 15;198:110667.;doi: 10.1016/j.ecoenv.2020.110667. (IF 4.872)

103. Fan Wang,Jian Yang,Yongsheng Li,Qixin Zhuang,Jinlou Gu
Efficient enzyme-activated therapy based on the different locations of protein and prodrug in nanoMOFs
J Mater Chem B. 2020 Jul 28;8(28):6139-6147.;doi: 10.1039/d0tb01004a. (IF 5.344)

104. Jinheng Wang,Guangmeng Li,Chenggong Tu,Xiaoming Chen,Bin Yang,Yongliang Huo,Yi Li,Ai-Zheng Chen,Ping Lan,Yu Shrike Zhang,Maobin Xie
High-throughput single-cell analysis of exosome mediated dual drug delivery, in vivo fate and synergistic tumor therapy
Nanoscale. 2020 Jul 2;12(25):13742-13756.;doi: 10.1039/d0nr02344b. (IF 6.895)

105. Yujing Zhang,Huanfeng Bian,Yu Ma,Yuanyuan Xiao,Fang Xiao
Cr(VI)-induced overactive mitophagy contributes to mitochondrial loss and cytotoxicity in L02 hepatocytes
Biochem J. 2020 Jul 31;477(14):2607-2619.;doi: 10.1042/BCJ20200262. (IF 4.097)

106. Qingqing Han,Lijuan Han,Fangfang Tie,Zhenhua Wang,Chengjun Ma,Ji Li,Honglun Wang,Gang Li
(20S)-Protopanaxadiol Ginsenosides Induced Cytotoxicity via Blockade of Autophagic Flux in HGC-27 Cells
Chem Biodivers. 2020 Jul;17(7):e2000187.;doi: 10.1002/cbdv.202000187. (IF 2.039)

107. Kai Zheng,Jingxin Ma,Yifei Wang,Zhendan He,Kejun Deng
Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3
Mol Nutr Food Res. 2020 Jul;64(14):e1901231.;doi: 10.1002/mnfr.201901231. (IF 5.309)

108. Hongxia Tang,Chaoqun Li,Yue Zhang,Hongyue Zheng,Ying Cheng,Jingjing Zhu,Xiaojie Chen,Zhihong Zhu,Ji-Gang Piao,Fanzhu Li
Targeted Manganese doped silica nano GSH-cleaner for treatment of Liver Cancer by destroying the intracellular redox homeostasis
Theranostics. 2020 Aug 2;10(21):9865-9887.;doi: 10.7150/thno.46771. (IF 8.579)

109. Yao Hao,Yao Huang,Jingyi Chen,Jiadai Li,Yuncong Yuan,Mingzhen Wang,Lingling Han,Xiu Xin,Hailong Wang,Danqing Lin,Fang Peng,Fang Yu,Congyi Zheng,Chao Shen
Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling
CELL PROLIFERAT. 2020 Aug;53(8):e12869.;doi: 10.1111/cpr.12869. (IF 5.753)

110. Xiuge Gao,Xiangchun Ruan,Hui Ji,Lin Peng,Yawei Qiu,Dan Yang,Xinhao Song,Chunlei Ji,Dawei Guo,Shanxiang Jiang
Maduramicin triggers methuosis-like cell death in primary chicken myocardial cells
Toxicol Lett. 2020 Oct 15;333:105-114.;doi: 10.1016/j.toxlet.2020.07.025. (IF 3.569)

111. Youlu Chen,Yong Zeng,Xiaowei Zhu,Lifu Miao,Xiaoyu Liang,Jianwei Duan,Huiyang Li,Xinxin Tian,Liyun Pang,Yongxiang Wei,Jing Yang
Significant difference between sirolimus and paclitaxel nanoparticles in anti-proliferation effect in normoxia and hypoxia: The basis of better selection of atherosclerosis treatment
Bioact Mater. 2020 Oct 1;6(3):880-889.;doi: 10.1016/j.bioactmat.2020.09.005.

112. Yun Yang,Yang Zhang,Jufang Gao,Wenping Xu,Zhiping Xu,Zhong Li,Jiagao Cheng,Liming Tao
Pyrethrum extract induces oxidative DNA damage and AMPK/mTOR-mediated autophagy in SH-SY5Y cells
Sci Total Environ. 2020 Oct 20;740:139925.;doi: 10.1016/j.scitotenv.2020.139925. (IF 6.551)

113. Ping Zhang,Hongfei Ni,Yang Zhang,Wenping Xu,Jufang Gao,Jiagao Cheng,Liming Tao
Ivermectin confers its cytotoxic effects by inducing AMPK/mTOR-mediated autophagy and DNA damage
Chemosphere. 2020 Nov;259:127448.;doi: 10.1016/j.chemosphere.2020.127448. (IF 5.778)

114. Wanwei Yang,Cuihua Jiang,Zhiguo Wang,Jian Zhang,Xiaodong Mao,Guofang Chen,Xiaoming Yao,Chao Liu
Cyclocarya paliurus extract attenuates hepatic lipid deposition in HepG2 cells by the lipophagy pathway
Pharm Biol. 2020 Dec;58(1):838-844.;doi: 10.1080/13880209.2020.1803365. (IF 2.971)

115. Shaohong Fang,Xin Wan,Xiaoyi Zou,Song Sun,Xinran Hao,Chenchen Liang,Zhenming Zhang,Fangni Zhang,Bo Sun,Hulun Li,Bo Yu
Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway
Cell Death Dis. 2021 Jan 18;12(1):88.;doi: 10.1038/s41419-020-03357-1. (IF 6.304)

116. Shuai Wang,Rong Guo,Yongxia Su,Chen Yang,Yazhou Guo,Chengjian Tan,Baoyu Zhao
Swainsonine promotes apoptosis by impairing lysosomal function and inhibiting autophagic degradation in rat primary renal tubular epithelial cells
CHEM-BIOL INTERACT. 2021 Feb 25;336:109319.;doi: 10.1016/j.cbi.2020.109319. (IF 3.723)

117. Xixi Cai,Shengyang Chen,Jieping Liang,Mingyu Tang,Shaoyun Wang
Protective effects of crimson snapper scales peptides against oxidative stress on Drosophila melanogaster and the action mechanism
Food Chem Toxicol. 2021 Feb;148:111965.;doi: 10.1016/j.fct.2020.111965. (IF 4.679)

118. Huanyu Zhang,Zhe Zhang,Yonghao Huang,Siyuan Qin,Li Zhou,Ningna Weng,Jiayang Liu,Mei Yang,Xiaodian Zhang,Yanda Lu,Lin Ma,Shaojiang Zheng,Qifu Li
Repurposing antitussive benproperine phosphate against pancreatic cancer depends on autophagy arrest
Mol Oncol. 2021 Feb;15(2):725-738.;doi: 10.1002/1878-0261.12854. (IF 6.574)

119. Jin Hou,Ling Zhao,Huaqiao Tang,Xiaoli He,Gang Ye,Fei Shi,Min Kang,Helin Chen,Yinglun Li
Silver Nanoparticles Induced Oxidative Stress and Mitochondrial Injuries Mediated Autophagy in HC11 Cells Through Akt/AMPK/mTOR Pathway
Biol Trace Elem Res. 2021 Mar;199(3):1062-1073.;doi: 10.1007/s12011-020-02212-w. (IF 2.639)

120. Jiahua Zheng,Shaochai Wei,Tingting Xiao,Guanwu Li
LC3B/p62-mediated mitophagy protects A549 cells from resveratrol-induced apoptosis
Life Sci. 2021 Apr 15;271:119139.;doi: 10.1016/j.lfs.2021.119139. (IF 3.647)

121. Lu-Ying Duan,Jin-Wen Liu,Ru-Qin Yu,Jian-Hui Jiang
DNAzyme cascade circuits in highly integrated DNA nanomachines for sensitive microRNAs imaging in living cells
Biosens Bioelectron. 2021 Apr 1;177:112976.;doi: 10.1016/j.bios.2021.112976. (IF 10.257)

122. Jian Chen,Hui Liu,Xiufang Li,Jianbing Li,Rongdi Tang,Zhiwei Deng,Yanjing Yang,Shian Zhong
Dually acid- and GSH-triggered bis(β-cyclodextrin) as drugs delivery nanoplatform for effective anticancer monotherapy
Nanotechnology. 2021 Apr 2;32(14):145714.;doi: 10.1088/1361-6528/abd7b1. (IF 3.551)

123. Yanpin Gu,Yongcheng Zhu,Guoliang Deng,Songjun Liu,Yang Sun,Wen Lv
Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation
Int Immunopharmacol. 2021 Apr;93:107375.;doi: 10.1016/j.intimp.2021.107375. (IF 3.943)

124. Xiong Chen,Dapeng Wang,Baofei Sun,Chunyan Liu,Kai Zhu,Aihua Zhang
GBE attenuates arsenite-induced hepatotoxicity by regulating E2F1-autophagy-E2F7a pathway and restoring lysosomal activity
J Cell Physiol. 2021 May;236(5):4050-4065.;doi: 10.1002/jcp.30147. (IF 5.546)